Protein Alignment Mcm5 and mcm-3

DIOPT Version :10

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_506706.1
• Gene: mcm-3 / 180010
• WormBaseID: WBGene00003155
• Length: 812
• Species: Caenorhabditis elegans
• Alignment Length: 696
• Identity: 217/696 - (31%)
• Similarity: 348/696 - (50%)
• Gaps: 105/696 - (15%)

  Fly     1 MEGFDDAGVFFSDNFGGDNQQDAQINLQAVKKKYKEFIRTFNEENFFYKYRDTLKRNYLNGRYFL 65
            |:|..| |:|.      |..:||:  .|.:.::|..|:.  |:.:.|: ||..:.:...:|...|
 Worm     1 MDGQAD-GMFI------DRAEDAR--KQEITEQYLNFLD--NQADTFH-YRQKIVKMMNDGESRL 53

  Fly    66 EIEMEDLVGFDETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLSS----- 125
            .:.::::.......|:.|..|....:...:.|.:...:.            .|:|.::.:
 Worm    54 VMNLDEIREILPERAEGLLTQSVLEMNCLQSALQMAINR------------SDVQAVVKTGFHVG 106

  Fly   126 --------NANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPG 182
                    :.||   |.|||..:..||...||:...|.:..|.......|.:.:.|:.....:..
 Worm   107 FEGTFGERHVNP---RTLKSSYLGNLVCCEGIVTKCSTVRQKLLTSVHYCPATNKVLEKKFADFT 168

  Fly   183 LEGYALPRKCNTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRS 247
            :...|:... |.......|.||:..|   ......|.||..:||||:..|.|::||.:....|..
 Worm   169 MLDTAVTNN-NYPTEDENKNPLETEF---GHSVYKDHQTFTIQELPESAPAGQLPRAVDCVADLD 229

  Fly   248 LCERVVPGNRVLIQGIYSIRKVGKPSRRDGRE----KAVVGVRAPYMRVVGITVDSEGAGAISRY 308
            |.:||.||:||.|.|::.:    .|::::|..    ::::.:.  :::::...|          .
 Worm   230 LADRVKPGDRVRIIGVFRV----LPNKQNGVSSGSFRSIIIIN--HIQMLSKEV----------I 278

  Fly   309 SNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDIN 373
            .|....:.:..|:::.|.:.:|.|::||||||.|..:.|||:.|:|.||..|.|.:|...|||||
 Worm   279 PNFEPQDVKDVRKISKSRNPFELLARSLAPSICGHEETKKALLCLLLGGMEKILNNGSRLRGDIN 343

  Fly   374 VLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGV 438
            |||:|||..||||||::|.::||.|:.|:|:|||..||||:|..||.:....:|.|||||||.||
 Worm   344 VLLIGDPSVAKSQLLRYVLRMAPRAITTTGRGSSGVGLTAAVTTDPDSGERRLEAGAMVLADRGV 408

  Fly   439 VCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKGE-ENID 502
            |||||||||.:.||.||||.|||..::|:||||...||:|||||||||.::||::..|.. |||.
 Worm   409 VCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHAKLNARCSVLAAANPVYGRYNPFKSPMENIG 473

  Fly   503 FMPTILSRFDMIFIVKDIHDESRDITLAKHIINVH--------------------------LSSN 541
            ...::|||||:||::.|.||..:|..:|:|::.:|                          :.:.
 Worm   474 MQDSLLSRFDLIFVLLDEHDADKDANVAEHVLKLHTYRTQGEADGTVLPMGGGVETISTINMETK 538

  Fly   542 KSAPSEPAEGE----------ISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQE 596
            |::.|...|..          :::...:||||..|: ..|:|::.|.|.:...|..:||   ...
 Worm   539 KASSSIYEENTQWAGIQDTKILTMDFMRKYIHLARS-VQPKLTDEATEYISEVYADIRS---FDI 599

  Fly   597 KASDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRL 642
            ..:|:..::|:|.||||.:||:|.::||.|.......|...:|..|
 Worm   600 TKTDQERTMPVTARQLETLIRLSTAIAKARFSKKVEREDTEKAYNL 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	14/93 (15%)
		MCM	128..648	CDD:214631	194/556 (35%)
mcm-3	NP_506706.1	MCM	114..649	CDD:475121	194/559 (35%)