DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm5 and mcm-7

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_504199.1	Gene:	mcm-7 / 178831	WormBaseID:	WBGene00003159	Length:	730	Species:	Caenorhabditis elegans

Alignment Length:	778	Identity:	244/778 - (31%)
Similarity:	372/778 - (47%)	Gaps:	141/778 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FDDAGVFFSDNFGGDN-------------QQDAQ---INLQAVKK-------KYKEFIRTFNEEN 45
            ||:   ::.||..|..             ::|.|   :|:..:|:       :..|.| |.|.:.
Worm    21 FDE---YYVDNEDGSGKAFPYRDQVFEIARRDKQAIVVNVDHIKESDIPDALELSEAI-TSNTKR 81

  Fly    46 FFYKYRDTLK---RNYLNGRYFLEIEMEDLVGF--------------DETLADKLNKQPTEHLEI 93
            :...::||:.   ::||..:....|:..|...|              :.:|.||..|.|.:.|:.
Worm    82 YEVLFKDTISDMIQDYLGDKQAPVIDALDAYMFQRLHMDRNEGAANEEVSLQDKRKKYPPQLLQR 146

  Fly    94 FEEAAREVADEITAPRPEHEEHMHDIQILLSSNANPTNIRQLKSDCVSKLVKIAGIIVAASGISA 158
            ||                       :.......|:.|.:|.:|:..:..||.:.|:::.|:.:..
Worm   147 FE-----------------------VYFTTDDAAHETCVRNIKATEIGHLVSMKGVVIRATEVKP 188

  Fly   159 KATRMSIQCLSCSTVIPNLKVNPGLEG--YALPRKCNTEQA------GRPKCPLDPFFIMPDKCK 215
            ....|:..|.:|:.     :|...::|  :..|..|..::.      ||....|       ...|
Worm   189 CVEVMTYTCDTCAA-----EVYQPVKGMQFTPPVNCPNKECVEAKANGRLHMQL-------RGSK 241

  Fly   216 CVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQGIY-SIRKVGKPSRRDGRE 279
            .|.||.||:|||.:.||.|.|||.:.:.....:..:...||.|.:.|:: .|.:.|  .|..|..
Worm   242 FVKFQELKIQELSEQVPVGSIPRTMTVHVYGEMTRKCNTGNVVHVSGVFLPIMQSG--FRPTGGL 304

  Fly   280 KAVVGVRAPYMRVVGITVDSEGAGAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSR 344
            .|...:.|.|:.    .:|..     ..::.:.|.|.|..||   .||.||.|:.|:||.|||..
Worm   305 VADTYLEAHYIN----NLDDN-----PTFNGVQSAELEVLRR---KGDNYETLAASIAPEIFGHV 357

  Fly   345 DIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAA 409
            |:||.:...|.||: ....:|:..||.||||::||||.||||||.:|.::||.:.||:|:|||..
Worm   358 DVKKCLLMALVGGN-DNSSNGMKIRGCINVLMMGDPGVAKSQLLGYVNRLAPRSQYTTGRGSSGV 421

  Fly   410 GLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTT 474
            ||||:|||||.|....:||||:||||||:.||||||||.:.||.||||.|||||||||||||.||
Worm   422 GLTAAVMKDPVTGEMSLEGGALVLADGGICCIDEFDKMMDHDRTAIHEVMEQQTISIAKAGIMTT 486

  Fly   475 LNSRCSVLAAANSIFGRWDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHL 538
            ||:|.:::||||..:||::..:. |:|:|....:|||||:|.:::|..|...|..||:||..||
Worm   487 LNARTAIIAAANPAYGRYNPNRSIEQNVDLPAALLSRFDLILLMQDKADRENDKILAEHITYVH- 550

  Fly   539 SSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRL 603
             .:...|:...:..|||.|.::||..|:|:. |.:..|..|::...||.||..|   ..:||...
Worm   551 -QHGCHPNREKKDLISLETLREYISLCKTYT-PTVDPALRERIVEAYVEMRRDA---RYSSDPTF 610

  Fly   604 SIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTLDAAMTGSLAGAEGFTTEEDQ 668
            ..|   |.:..::|::.:.||:||.....:..|.|||||.|                 |..:..:
Worm   611 VSP---RMILGIVRMATARAKLRLSTIVDESDVEEALRLMQ-----------------FAKDSLR 655

  Fly   669 ETLNRIEKQL---KRRFAI--------GSQVSEQNILQDFLRQKYEERTVMKVIHTMIRRGEL 720
            ...|:|||::   ...||:        .:.::..|.:|...|:...|..:.|.:......|.|
Worm   656 PEQNKIEKRMAPVDAAFAVLRELYHADNAPIAISNAIQRCARKGISEVALKKCLDQYTANGLL 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	20/116 (17%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	201/529 (38%)
mcm-7	NP_504199.1	MCM_N	16..178	CDD:291233	34/183 (19%)
		MCM	162..651	CDD:214631	201/541 (37%)
		P-loop_NTPase	385..524	CDD:304359	85/138 (62%)
		CarD_CdnL_TRCF	<619..715	CDD:294393	24/112 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820