Protein Alignment Mcm5 and mcm-6

DIOPT Version :10

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_001023011.1
• Gene: mcm-6 / 176385
• WormBaseID: WBGene00003158
• Length: 810
• Species: Caenorhabditis elegans
• Alignment Length: 810
• Identity: 250/810 - (30%)
• Similarity: 389/810 - (48%)
• Gaps: 138/810 - (17%)

  Fly    13 DN-FGGDNQQDAQINLQAVKKKYKEFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIEMEDLVGFD 76
            || .||..||....:...|:.::.:|:::|.::...:.|:..:|......:..:.|.|:.|..|.
 Worm     2 DNIIGGQAQQVEDTDGTRVQNEFSKFLKSFKDQKNEFIYKSAMKELVQPEKNTIFINMQHLYKFS 66

  Fly    77 ETLADKLNKQ-------PTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLS-SNAN-PTNI 132
            ..||..:..|       ..|.|.:   |..:..||      ...:.|...|:.:| .|.: .|.:
 Worm    67 NNLATTIELQYYRVYPFMCEALHL---ATLDACDE------SERQQMFKKQLYVSLFNLDAKTKV 122

  Fly   133 RQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYALPRKC-NTEQ 196
            |:|.:|.|..||:|||.||....:..:.:|....|..|.....:::..   ..|..|.|| |.:.
 Worm   123 RELSADKVGGLVRIAGQIVRTHPVHPELSRACFVCEDCGVTTRDVQQQ---FRYTQPTKCANPQC 184

  Fly   197 AGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQ 261
            ..|.:..||     .:....||||.:::||....:|:|.|||.:.:.....:.|.|.||::..|.
 Worm   185 MNRTRFSLD-----VNSSTFVDFQKIRIQETQAELPRGSIPRTVDVIVRGEMVETVQPGDKCDIV 244

  Fly   262 G----IYSIRKVGKPSRR-----DGREKA-----------VVGVR---------APYMRVVGITV 297
            |    |..|.::..|..|     ..|.:|           .:|||         |.:::.....|
 Worm   245 GTLIVIPDIAQLSTPGLRAETSNQNRGRATDKSEGITGLKALGVRDLTYKMAFLACHIQQTESLV 309

  Fly   298 DSEGAGAISR------YSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFG 356
            ..:.:||:..      :|.:::::....::|:....|.:.:..||.|:|:|:.::|..:..||.|
 Worm   310 GGDASGAVEETDYLDLWSKMSTEDRATLKKMSDDKKIEKNIVDSLFPNIYGNHEVKLGVLLMLLG 374

  Fly   357 G-SRKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQ 420
            | ::|...:|...||||||.|:|||.|||||:||.||:.:|.|:|||||.||||||||:|:||.:
 Worm   375 GVAKKSRDEGTSLRGDINVCLVGDPSTAKSQVLKAVEEFSPRAIYTSGKASSAAGLTAAVVKDEE 439

  Fly   421 TRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAA 485
            :..||:|.||::|||.||.||||||||...|:||||||||||||||.|||:..|||:|.|:||||
 Worm   440 SFEFVIEAGALMLADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGVKATLNARASILAAA 504

  Fly   486 NSIFGRWDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPA 549
            |.:.||:|.::. :.|:.....|:||||:.|::.|..:|..|..:|:.|::     |..|.||..
 Worm   505 NPVNGRYDRSRPLKYNVQMSAPIMSRFDLFFVLVDECNEVTDYAIARRILD-----NHRAISEHT 564

  Fly   550 EGE--ISLSTFKKYIHYCRTHC-GPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQ 611
            |.:  ..:...||||.:.|  | .|::|:.|.|.|...|..:|.........|..|    |||||
 Worm   565 ERDSVYKIDDIKKYIAFAR--CFKPKISDKAAETLVREYKKLRMSDSNNAATSSWR----ITVRQ 623

  Fly   612 LEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTL-----DAAMTG---------------SL 656
            ||:::|:||:||::........|||.:|..|...|.:     |.|:..               :.
 Worm   624 LESLVRLSEALARLHCGKEVLVEHVEKAAELLNKSIVRVEQPDIALDDDDFDNNIMVVEADKENQ 688

  Fly   657 AGAEGFTTEEDQETLNRIE-KQLKRRFAIGSQVSEQNIL-------------------------- 694
            .|.:....:.::|...:|: .:||..|....|:|:..:|
 Worm   689 RGDDSMDHDGEKENAPKIDIAKLKISFKEYKQLSDVLVLHMRSDEDNQGEDEYDGVKQSALVEWY 753

  Fly   695 -----------QDFLRQK-YEERTVMKVIH 712
                       :||..|| ..||.:.::||
 Worm   754 LSTIEADLETEEDFNVQKTICERVIHRLIH 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	19/101 (19%)
		MCM	128..648	CDD:214631	204/561 (36%)
mcm-6	NP_001023011.1	MCM_N	21..115	CDD:464206	19/102 (19%)
		MCM	119..660	CDD:214631	204/559 (36%)
		MCM6_C	710..807	CDD:465688	14/74 (19%)