Protein Alignment Mcm5 and mcm-2

DIOPT Version :10

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_001022416.1
• Gene: mcm-2 / 174841
• WormBaseID: WBGene00003154
• Length: 881
• Species: Caenorhabditis elegans
• Alignment Length: 744
• Identity: 237/744 - (31%)
• Similarity: 372/744 - (50%)
• Gaps: 83/744 - (11%)

  Fly     5 DDAGVFFSDNFGG----DNQQDAQINLQAVKKKYKEFIRTFNEE-NFFYKYRDTLKRNYLNGRYF 64
            :|..|...:|..|    |:..|..: .:.:::::|.|:|:|:|. |...||...:|....:.|..
 Worm   140 EDIPVDILENIRGRTIRDHVSDEAV-AKEIERRFKNFLRSFHEPGNKQTKYIQMIKSMAADNRES 203

  Fly    65 LEIEMEDLV--GFDETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLSSNA 127
            ||:...||.  ..::.::..|.:.|.|.|.|.:.||.||   :....|.:....::|::.:|...
 Worm   204 LEVSFTDLSDDNGEQNISYFLPEAPNEMLAIMDRAATEV---VMNMYPFYSRVCNEIKVRISQLP 265

  Fly   128 NPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYAL-PRK 191
            ...:||.|:...::.|::.||::..||||..:...:...|::|              ||.| |..
 Worm   266 VEEDIRMLRQVHLNMLIRTAGVVTIASGILPQLAVVKYDCVAC--------------GYLLGPFV 316

  Fly   192 CNTEQAGRPK-CP----LDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCER 251
            ...::..||. ||    ..||.:..:.....::|.:.:||.|:.|..|.:||...:.....||:.
 Worm   317 QQNDEEVRPTICPSCQGKGPFELNVENTVYHNYQRITMQESPNKVAAGRLPRSKDVILLGDLCDS 381

  Fly   252 VVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVVGITVDSEGAGAISRYSNITSDEE 316
            ..||:.:.:.|:|:....|..:.:.|.......:.|.:     ||...:.|.     ..:|.::.
 Worm   382 CKPGDEIEVTGVYTNNFDGSLNYKQGFPVFNTLIHANH-----ITNKDKMAS-----DQLTDEDI 436

  Fly   317 EHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCR-RGDINVLLLGDP 380
            :..|.::...:|.:|:..|:||||:|..|:|:||...||.|..|. |....| ||||||||.|||
 Worm   437 KAIRELSQDPNISQRVFSSIAPSIYGHDDVKRAIALALFRGEAKN-PGAKHRLRGDINVLLCGDP 500

  Fly   381 GTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFD 445
            ||||||.|::...:||.:|.|:|:|:||.||||.|.:.|.||.:.:|.|||||||.||..|||||
 Worm   501 GTAKSQFLRYAAHIAPRSVLTTGQGASAVGLTAYVQRHPVTREWTLEAGAMVLADKGVCLIDEFD 565

  Fly   446 KMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKG-EENIDFMPTILS 509
            ||.:.||.:||||||||:|||:||||.|:|::||:|:||:|.|.||::.|:. .||:|....|||
 Worm   566 KMSDQDRTSIHEAMEQQSISISKAGIVTSLHARCTVIAASNPIGGRYNPTRTFAENVDLTEPILS 630

  Fly   510 RFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGE---------------ISLSTFK 559
            |||::.:::|..|...|..|||.::..|.:.:..|.....||:               |.....:
 Worm   631 RFDVLCVIRDSVDSVEDERLAKFVVGNHRTHHPDAKKIVKEGDELEEDQMDERTGVRLIPQDLLR 695

  Fly   560 KYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAK 624
            |||.|.|..|.|.|.|...||..:.:..||       |.|....|:.||||.:|::||:||:.||
 Worm   696 KYIIYAREKCHPTLPEQHSEKFSNIFAQMR-------KESMATGSVAITVRHVESMIRLSEAHAK 753

  Fly   625 IRLQPFATDEHVNEALRLFQVSTLDAAMTGSLAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVS 689
            :.|:.:..||....|:|:.               .|.|...:....:..::|...|........:
 Worm   754 LHLRSYVNDEDCAAAIRVM---------------LESFVNTQKASIMRMMKKTFSRHLTENRSAN 803

  Fly   690 E--QNILQDFLRQKYEERTVMKVIHTMIR 716
            |  ..||:..:||:....|......|:::
 Worm   804 ELLLFILKQLIRQQMHYATARAAAGTILQ 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	25/96 (26%)
		MCM	128..648	CDD:214631	194/542 (36%)
mcm-2	NP_001022416.1	MCM2_N	48..>116	CDD:403724
		MCM_N	169..262	CDD:464206	25/95 (26%)
		MCM	270..777	CDD:214631	195/553 (35%)