DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm5 and Mcm7

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_032594.1	Gene:	Mcm7 / 17220	MGIID:	1298398	Length:	719	Species:	Mus musculus

Alignment Length:	751	Identity:	236/751 - (31%)
Similarity:	378/751 - (50%)	Gaps:	122/751 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KKKYKEFIRTFNEENFF----YKYRDTLKRNYLNGRYFLEIEMEDLVGFDETLADKLNKQPTEHL 91
            |:|.|:|::.|..||..    :||...|.......:..|.::::|:...|..|.|.:.:....:.
Mouse    10 KEKVKKFLQEFYYENELGKKQFKYGTQLVHLAHREQVALYVDLDDIAEDDPELVDSICENAKRYS 74

  Fly    92 EIFEEAAREVADE-------------------------------ITAPRPEH-EEHMHDIQILL- 123
            .:|.:..:|:..|                               :..|:.:: .|.|...::..
Mouse    75 RLFGDVVQELLPEYKEKEVVNKDVLDVYIEHRLMMEQRSRDPGAVRNPQNQYPSELMRRFELYFR 139

  Fly   124 -SSNANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYA 187
             .|::.|..||::::|.|.||:.:.||:...|.:..:....:..|..|           |.|.|.
Mouse   140 GPSSSKPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQC-----------GAETYQ 193

  Fly   188 -------LP------RKCNTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRH 239
                   :|      ::|.|.::|      ...::.....|.|.||.:|:||..|.||.|.|||.
Mouse   194 PIQSPTFMPLIMCPSQECQTNRSG------GRLYLQTRGSKFVKFQEMKIQEHSDQVPVGNIPRS 252

  Fly   240 LQLFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRA-PYMR---VVGITV--- 297
            :.:..:........||:.|.:.||:      .|..|.|.::...|:.: .|:.   :|.:|.
Mouse   253 ITVVLEGENTRIAQPGDHVSVTGIF------LPVLRTGFQQMAQGLLSETYLEAHWIVKMTKSDD 311

  Fly   298 DSEGAGAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRL 362
            |..|||.:|      |:|    .:..|..|.||:|:.|:||.|:|..|:|||:..:|.||. .:.
Mouse   312 DVSGAGELS------SEE----LKQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGV-DQS 365

  Fly   363 PDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVME 427
            |.|:..||:|::.|:||||.||||||.:::::||.:.||:|:|||..||||:|::|..:....:|
Mouse   366 PQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLE 430

  Fly   428 GGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRW 492
            |||:||||.||.||||||||.|.||.||||.|||||||||||||.||||:|||:|||||..:||:
Mouse   431 GGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRY 495

  Fly   493 DDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGE-ISL 555
            :..:. |:|:.....:|||||::::::|..|...|:.||:||..||..|.:    .||:.| :.:
Mouse   496 NPRRSLEQNVQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQ----PPAQFEPLDM 556

  Fly   556 STFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISE 620
            ...::||..|... .|.:.|:..:.:.:.||.||..|...:.|:      ..:.|.|.|::|:|.
Mouse   557 KLMRRYIAMCHER-QPTVPESLADYITAAYVEMRREARASKDAT------YTSARTLLAILRLST 614

  Fly   621 SLAKIRLQPFATDEHVNEALRLFQVSTLDAAMTGSLAGAEGFT--TEEDQETLNRIEKQL--KRR 681
            :||::|:......|.||||:||.::|      ..||.|.:|.|  |:...:.:....::|  :.|
Mouse   615 ALARLRMVDIVEKEDVNEAIRLMEMS------KDSLLGEKGQTARTQRPADVIFATIRELVSRGR 673

  Fly   682 FAIGSQVSEQNILQDF-------LRQKYEERTVMKV 710
            ....|:..::.|.:.|       ...:|||..|.:|
Mouse   674 SVHFSEAEQRCISRGFTPAQFQAALDEYEELNVWQV 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	21/130 (16%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	198/541 (37%)
Mcm7	NP_032594.1	MCM_N	12..165	CDD:291233	28/152 (18%)
		MCM	145..641	CDD:214631	198/546 (36%)
		P-loop_NTPase	376..515	CDD:304359	81/138 (59%)
		Arginine finger	513..516		2/2 (100%)
		Interaction with RAD17. /evidence=ECO:0000250	521..564		14/46 (30%)
		Interaction with ATRIP. /evidence=ECO:0000250	577..719		38/145 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820