DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mcm5 and Mcm6

DIOPT Version :9

Sequence 1:NP_524308.2 Gene:Mcm5 / 41296 FlyBaseID:FBgn0017577 Length:733 Species:Drosophila melanogaster
Sequence 2:NP_032593.1 Gene:Mcm6 / 17219 MGIID:1298227 Length:821 Species:Mus musculus


Alignment Length:775 Identity:243/775 - (31%)
Similarity:374/775 - (48%) Gaps:107/775 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 GDNQQDAQINLQAVKKKYK---EFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIEMEDLVGFDET 78
            |...|..::..:..:|..|   :|:..|...:...||....:......|..|.:...||..|::.
Mouse    10 GAGSQHPEVRDEVAEKCQKLFLDFLEEFQGSDGEIKYLQFAEELIRPERNTLVVSFADLEQFNQQ 74

  Fly    79 LADKLNKQPTEHLEIFEEAARE----VADEITAPRPEHEEHMHDIQILLSSNANPTNIRQLKSDC 139
            |:..:.:   |...::....|.    |.|....|      ...|..:..........||:|.|..
Mouse    75 LSTTIQE---EFYRVYPYLCRALKTFVKDRKEIP------FAKDFYVAFQDLPTRHKIRELTSSR 130

  Fly   140 VSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYALPRKC-NTEQAGRPKCP 203
            :..|.:|:|.:|....:..:....:..||.|.|||.:::..   ..|..|..| |...|.|.:  
Mouse   131 IGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIKDVEQQ---FKYTQPNICRNPVCANRKR-- 190

  Fly   204 LDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQG----IY 264
               |.:..:|.:.||||.:::||....:|:|.|||.|::.......|....|:|....|    :.
Mouse   191 ---FLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDRCDFTGALIVVP 252

  Fly   265 SIRKVGKPSRR----------DGREK------AVVGVRAPYMRVV--------------GITVDS 299
            .:.|:..|..|          ||.|.      ..:|||....|:|              |..:..
Mouse   253 DVSKLSTPGARAETNSRVSGADGYETEGIRGLRALGVRDLSYRLVFLACHVAPTNPRFGGKELRD 317

  Fly   300 EGAGAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPD 364
            |...|.|..:.:|..|.|....|:...::|..|..||.|:|.|:.::|:.:..|||||..|...:
Mouse   318 EEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGE 382

  Fly   365 GLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGG 429
            |...||||||.::|||.|||||.||.|::.:|.|||||||.||||||||:|::|.::..||:|.|
Mouse   383 GTSLRGDINVCIVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAG 447

  Fly   430 AMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDD 494
            |::|||.||.||||||||...|:||||||||||||||.|||:..|||:|.|:|||||.:.|.:|.
Mouse   448 ALMLADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGHYDR 512

  Fly   495 TKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGEISLSTF 558
            :|. ::||:....|:||||:.||:.|..:|..|..:|:.|:::|     |...|..:...||...
Mouse   513 SKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH-----SRIEESIDRVYSLDDI 572

  Fly   559 KKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLA 623
            ::|:.:.| ...|::|:.:.:.:..:|..:|    |::.:...:.|..|||||||::||:|||:|
Mouse   573 RRYLLFAR-QFKPKISKESEDFIVEQYKRLR----QRDGSGVTKSSWRITVRQLESMIRLSESMA 632

  Fly   624 KIRLQPFATDEHVNEALRL-----FQVSTLDAAM-------------TGSLAG----------AE 660
            ::........:||.||.||     .:|.|.|..:             .|.:.|          ..
Mouse   633 RMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMETDEGQGGVNGHADSPAPVNRFN 697

  Fly   661 GFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQKYEERTVMKVIHTMIRRGEL 720
            |.:.:..|||:::  ..|:..||...::|  |::...||:..||..     .:.::|.||
Mouse   698 GSSEDASQETVSK--PSLRLGFAEYCRIS--NLIVLHLRKMEEEED-----ESALKRSEL 748

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mcm5NP_524308.2 MCM_N 31..124 CDD:405270 18/99 (18%)
MCM 128..648 CDD:214631 203/560 (36%)
Mcm6NP_032593.1 MCM_N 29..139 CDD:291233 22/118 (19%)
MCM 119..657 CDD:214631 202/555 (36%)
P-loop_NTPase <447..534 CDD:304359 53/86 (62%)
Arginine finger 528..531 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 676..708 5/31 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1241
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D232729at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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