DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm5 and Mcm5

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001289469.1	Gene:	Mcm5 / 17218	MGIID:	103197	Length:	734	Species:	Mus musculus

Alignment Length:	738	Identity:	502/738 - (68%)
Similarity:	619/738 - (83%)	Gaps:	11/738 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEGFDDAGVFFSDNFGGD-NQQDAQINLQAVKKKYKEFIRTF----NEENFFYKYRDTLKRNYLN 60
            |.||||.|:|:||:|||| ..::.|.....:::::|||:|.:    :...|.:||||.|||:|..
Mouse     1 MSGFDDPGIFYSDSFGGDPGAEEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNL 65

  Fly    61 GRYFLEIEMEDLVGFDETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLSS 125
            |.|::|:|||||..|||.|||.|:|||.|||::.||||:|||||:|.|||..:|.:.|||::|.|
Mouse    66 GEYWIEVEMEDLASFDEELADHLHKQPAEHLQLLEEAAKEVADEVTRPRPAGDELLQDIQVMLKS 130

  Fly   126 NANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYALPR 190
            :|:|::||.||||.:|.||||.|||::||.:.|||||:||||.||...:.|:.:.||||||||||
Mouse   131 DASPSSIRILKSDMMSHLVKIPGIIISASAVRAKATRISIQCRSCHNTLTNIAMRPGLEGYALPR 195

  Fly   191 KCNTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPG 255
            |||.:|||||||||||:||||||||||||||||||||||.||.||:|||:||:|||.||::||||
Mouse   196 KCNMDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPG 260

  Fly   256 NRVLIQGIYSIRKVG-KPSRRDGREKAVVGVRAPYMRVVGITVDSEGAGAISRYSNITSDEEEHF 319
            |||.|.|||||:|.| .||:  ||::..||:|:.|:||:||.||::|:|. |...:::..|||.|
Mouse   261 NRVTIMGIYSIKKFGLNPSK--GRDRVGVGIRSSYIRVLGIQVDTDGSGR-SFAGSVSPQEEEEF 322

  Fly   320 RRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAK 384
            ||:||..:|||.:|:|::|||||..|:||||.|:|||||||||||||.||||||:|:||||||||
Mouse   323 RRLAALPNIYELISKSISPSIFGGMDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAK 387

  Fly   385 SQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMRE 449
            |||||||||.:||.|||||||||||||||||::||.:|||:||||||||||||||||||||||||
Mouse   388 SQLLKFVEKCSPIGVYTSGKGSSAAGLTASVIRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMRE 452

  Fly   450 DDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKGEENIDFMPTILSRFDMI 514
            ||||||||||||||||||||||||||||||||||||||:|||||:||||:|||||||||||||||
Mouse   453 DDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMI 517

  Fly   515 FIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGE 579
            |||||.|:|.||:.||||::.:|:|:  ...::..||||.|:..||:|.|||..||||||..|.|
Mouse   518 FIVKDEHNEERDMMLAKHVMTLHVSA--LTQTQAVEGEIDLAKMKKFIAYCRARCGPRLSAEAAE 580

  Fly   580 KLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQ 644
            |||:||::|||||.|.|:.||:|.|||||||||||::||:|:|:|::||||||:..|.|||||||
Mouse   581 KLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQ 645

  Fly   645 VSTLDAAMTGSLAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQKYEERTVMK 709
            |||||||::|:|:|.|||||:||||.|:||||||||||||||||||.:|:|||.:|||.|..:.|
Mouse   646 VSTLDAALSGNLSGVEGFTTQEDQEMLSRIEKQLKRRFAIGSQVSEHSIVQDFTKQKYPEHAIRK 710

  Fly   710 VIHTMIRRGELQHRMQRKMLYRI 732
            |:..|:||||:|||||||:|||:
Mouse   711 VLQLMLRRGEIQHRMQRKVLYRL 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	51/96 (53%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	373/520 (72%)
Mcm5	NP_001289469.1	MCM_N	35..130	CDD:379644	54/98 (55%)
		MCM	133..649	CDD:214631	372/516 (72%)
		Arginine finger	512..515		2/2 (100%)
		BREX_BrxC	<618..>730	CDD:380283	78/111 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849784
Domainoid	1	1.000	377	1.000	Domainoid score	I856
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4904
Inparanoid	1	1.050	1017	1.000	Inparanoid score	I282
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53983
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	1	1.000	-	-		FOG0004690
OrthoInspector	1	1.000	-	-		oto92195
orthoMCL	1	0.900	-	-		OOG6_102165
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R695
SonicParanoid	1	1.000	-	-		X3292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800