DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mcm5 and Mcm4

DIOPT Version :10

Sequence 1:NP_524308.2 Gene:Mcm5 / 41296 FlyBaseID:FBgn0017577 Length:733 Species:Drosophila melanogaster
Sequence 2:NP_032591.3 Gene:Mcm4 / 17217 MGIID:103199 Length:862 Species:Mus musculus


Alignment Length:711 Identity:233/711 - (32%)
Similarity:345/711 - (48%) Gaps:120/711 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 INLQAVKKKYKEFIRTF------NEENFFYK-----YRDTLKRNYLNGRYFLEIEMEDLVGFDET 78
            :|:...|:.::.|::.|      .|||....     |...|....:.|..||.:..|.:..|.:.
Mouse   156 VNVATCKENFQRFLQCFTDPLAKEEENVGIDITQPLYMQQLGEINITGEPFLNVNCEHIKSFSKN 220

  Fly    79 LADKLNKQPTEHLEIFEEAAREV-----ADEITAPRPEHEEHMHDIQILLSSNANPTNIRQLKSD 138
            |..:|...|.|.:..|:.|..|:     .|.|..         |.||:...:.....::|.|..:
Mouse   221 LYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILE---------HQIQVRPFNALKTKSMRNLNPE 276

  Fly   139 CVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYALPRKCNTEQAGRPKCP 203
            .:.:|:.|:|:::..|.:..:......||..|:.. ..::::.|.                    
Mouse   277 DIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHT-TRVEIDRGR-------------------- 320

  Fly   204 LDPFFIMPDKCKCV------------------DFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCE 250
                  :.:.|.||                  |.|.:||||.|:.:|.|:.|..:.||....|.:
Mouse   321 ------IAEPCSCVHCHTTHSMALIHNRSFFSDKQMIKLQESPEDMPAGQTPHTIVLFAHNDLVD 379

  Fly   251 RVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVV-----------GITVDSEGAGA 304
            :|.||:||.:.|||  |.|  |.|.:.|...|..|...::.|:           |:..::|    
Mouse   380 KVQPGDRVNVTGIY--RAV--PIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAE---- 436

  Fly   305 ISRYSNITSDEE-EHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLP-DGLC 367
                ..:.|::. :..:.::...||||||:.:|||||:...||||.|...||||:||... .|..
Mouse   437 ----QKLFSEKRVKLLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRG 497

  Fly   368 R-RGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAM 431
            : |.:||:||.|||||:|||||::|..:.|...|||||||||.||||.|||||:||..|::.||:
Mouse   498 KFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGAL 562

  Fly   432 VLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTK 496
            ||:|.|:.||||||||.|..|..:||.|||||:|||||||...||:|.|||||||.|..:|:..|
Mouse   563 VLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKK 627

  Fly   497 GE-ENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGEISLSTFKK 560
            .. |||....|:|||||:||::.|..||:.|..||.|:::::..|.:....|    .:.::..|.
Mouse   628 TTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEEQVEEE----FLDMAVLKD 688

  Fly   561 YIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKI 625
            ||.|..:...|||||.|.:.|...||.||       |....|..:....||||::||::|:.||:
Mouse   689 YIAYAHSTIMPRLSEEASQALIEAYVNMR-------KIGSSRGMVSAYPRQLESLIRLAEAHAKV 746

  Fly   626 RLQPFATDEHVNEALRLFQVSTLDAA------------MTGSLAGAEGFTTEEDQETLNRI 674
            |.........|.||.||.:.:...:|            :|..::.......||..|.|.::
Mouse   747 RFSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALRKL 807

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mcm5NP_524308.2 MCM_N 31..125 CDD:464206 25/109 (23%)
MCM 128..648 CDD:214631 201/552 (36%)
Mcm4NP_032591.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..71
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 90..121
MCM_N 162..263 CDD:464206 25/109 (23%)
MCM 266..769 CDD:214631 201/552 (36%)
Arginine finger 641..644 2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

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