Protein Alignment Mcm5 and Mcm2

DIOPT Version :10

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_032590.2
• Gene: Mcm2 / 17216
• MGIID: 105380
• Length: 904
• Species: Mus musculus
• Alignment Length: 743
• Identity: 237/743 - (31%)
• Similarity: 378/743 - (50%)
• Gaps: 124/743 - (16%)

  Fly    18 DNQQDAQI-----NLQAVK------------------KKYKEFIRTFNEEN----FFYKYRDTLK 55
            |.::|.::     ||:.:|                  .::|.|:||..:.:    |..:..|..|
Mouse   160 DGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCK 224

  Fly    56 RNYLNGRYFLEIEMEDLVGFDETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQ 120
            .|    |..|.:..|||...:..||..|.:.|.|.|:||:|||.||   :.|..|:::...:.|.
Mouse   225 EN----RESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEV---VLAMYPKYDRITNHIH 282

  Fly   121 ILLSSNANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVI------PNLKV 179
            :.:|.......:|.|:...:::|::.:|::.:.:|:..:.:.:...|..|:.|:      .|.:|
Mouse   283 VRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCSKCNFVLGPFCQSQNQEV 347

  Fly   180 NPGLEGYALPRKCNTEQAGRPKC-PLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLF 243
            .||        .|       |:| ...||.|..::....::|.:::||.|..|..|.:||.....
Mouse   348 KPG--------SC-------PECQSAGPFEINMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAI 397

  Fly   244 CDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMR------VVGITVDSEGA 302
            ....|.:...||:.:.:.|||.....|..:..:|.......:.|.::.      .||...|.:
Mouse   398 LLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATIILANHVAKKDNKVAVGELTDED-- 460

  Fly   303 GAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLC 367
              :...:.::.|::           |.|::..|:||||:|..|||:.:...||||..|. |.|..
Mouse   461 --VKMITGLSKDQQ-----------IGEKIFASIAPSIYGHEDIKRGLALALFGGEPKN-PGGKH 511

  Fly   368 R-RGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAM 431
            : ||||||||.|||||||||.||::|||:..|::|:|:|:||.||||.|.:.|.:|.:.:|.||:
Mouse   512 KVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGAL 576

  Fly   432 VLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDT- 495
            ||||.||..|||||||.:.||.:||||||||:|||:||||.|:|.:||:|:||||.|.||:|.:
Mouse   577 VLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSL 641

  Fly   496 KGEENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHL---SSNK-------------SA 544
            ...||:|....|:||||::.:|:|..|..:|..||:.::..|:   .|||             :.
Mouse   642 TFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKKDEGLTNGGTLEPAM 706

  Fly   545 PS----EPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSI 605
            |:    ||...|:    .||||.|.:....|:|::...:|:...|..:|       |.|....||
Mouse   707 PNTYGVEPLPQEV----LKKYIIYAKERVRPKLNQMDQDKVARMYSDLR-------KESMATGSI 760

  Fly   606 PITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTLDA-------AMTGSLAGAEGFT 663
            |||||.:|::||::|:.|::.|:.:..::.||.|:|:...|.:|.       :|..:.|....|
Mouse   761 PITVRHIESMIRMAEAHARMHLRDYVMEDDVNMAIRVMMESFIDTQKFSVMRSMRKTFARYLSF- 824

  Fly   664 TEEDQETLNRIEKQLKRRFAIGSQVSEQ 691
            ..::.:.|..|.|||     :..||:.|
Mouse   825 RRDNNDLLLFILKQL-----VAEQVTYQ 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	30/115 (26%)
		MCM	128..648	CDD:214631	190/554 (34%)
Mcm2	NP_032590.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..166		2/5 (40%)
		Interaction with KAT7. /evidence=ECO:0000269|PubMed:11278932	2..257		23/100 (23%)
		Interaction with DNJC9. /evidence=ECO:0000250|UniProtKB:P49736	61..130
		MCM2_N	72..182	CDD:403724	5/21 (24%)
		MCM_N	197..287	CDD:464206	29/96 (30%)
		MCM	291..803	CDD:214631	190/553 (34%)
		Arginine finger	655..658		2/2 (100%)