DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcm5 and Mcm2

DIOPT Version :9

Sequence 1:NP_524308.2 Gene:Mcm5 / 41296 FlyBaseID:FBgn0017577 Length:733 Species:Drosophila melanogaster
Sequence 2:NP_032590.2 Gene:Mcm2 / 17216 MGIID:105380 Length:904 Species:Mus musculus


Alignment Length:743 Identity:237/743 - (31%)
Similarity:378/743 - (50%) Gaps:124/743 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 DNQQDAQI-----NLQAVK------------------KKYKEFIRTFNEEN----FFYKYRDTLK 55
            |.::|.::     ||:.:|                  .::|.|:||..:.:    |..:..|..|
Mouse   160 DGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCK 224

  Fly    56 RNYLNGRYFLEIEMEDLVGFDETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQ 120
            .|    |..|.:..|||...:..||..|.:.|.|.|:||:|||.||   :.|..|:::...:.|.
Mouse   225 EN----RESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEV---VLAMYPKYDRITNHIH 282

  Fly   121 ILLSSNANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVI------PNLKV 179
            :.:|.......:|.|:...:::|::.:|::.:.:|:..:.:.:...|..|:.|:      .|.:|
Mouse   283 VRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCSKCNFVLGPFCQSQNQEV 347

  Fly   180 NPGLEGYALPRKCNTEQAGRPKC-PLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLF 243
            .||        .|       |:| ...||.|..::....::|.:::||.|..|..|.:||.....
Mouse   348 KPG--------SC-------PECQSAGPFEINMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAI 397

  Fly   244 CDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMR------VVGITVDSEGA 302
            ....|.:...||:.:.:.|||.....|..:..:|.......:.|.::.      .||...|.:  
Mouse   398 LLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATIILANHVAKKDNKVAVGELTDED-- 460

  Fly   303 GAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLC 367
              :...:.::.|::           |.|::..|:||||:|..|||:.:...||||..|. |.|..
Mouse   461 --VKMITGLSKDQQ-----------IGEKIFASIAPSIYGHEDIKRGLALALFGGEPKN-PGGKH 511

  Fly   368 R-RGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAM 431
            : ||||||||.|||||||||.||::|||:..|::|:|:|:||.||||.|.:.|.:|.:.:|.||:
Mouse   512 KVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGAL 576

  Fly   432 VLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDT- 495
            ||||.||..|||||||.:.||.:||||||||:|||:||||.|:|.:||:|:||||.|.||:|.: 
Mouse   577 VLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSL 641

  Fly   496 KGEENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHL---SSNK-------------SA 544
            ...||:|....|:||||::.:|:|..|..:|..||:.::..|:   .|||             :.
Mouse   642 TFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKKDEGLTNGGTLEPAM 706

  Fly   545 PS----EPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSI 605
            |:    ||...|:    .||||.|.:....|:|::...:|:...|..:|       |.|....||
Mouse   707 PNTYGVEPLPQEV----LKKYIIYAKERVRPKLNQMDQDKVARMYSDLR-------KESMATGSI 760

  Fly   606 PITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTLDA-------AMTGSLAGAEGFT 663
            |||||.:|::||::|:.|::.|:.:..::.||.|:|:...|.:|.       :|..:.|....| 
Mouse   761 PITVRHIESMIRMAEAHARMHLRDYVMEDDVNMAIRVMMESFIDTQKFSVMRSMRKTFARYLSF- 824

  Fly   664 TEEDQETLNRIEKQLKRRFAIGSQVSEQ 691
            ..::.:.|..|.|||     :..||:.|
Mouse   825 RRDNNDLLLFILKQL-----VAEQVTYQ 847

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mcm5NP_524308.2 MCM_N 31..124 CDD:405270 30/114 (26%)
MCM 128..648 CDD:214631 190/554 (34%)
Mcm2NP_032590.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..166 2/5 (40%)
Interaction with KAT7. /evidence=ECO:0000269|PubMed:11278932 2..257 23/100 (23%)
MCM2_N 72..182 CDD:289392 5/21 (24%)
MCM_N 198..310 CDD:291233 33/118 (28%)
MCM 291..803 CDD:214631 190/553 (34%)
P-loop_NTPase 485..>632 CDD:304359 88/147 (60%)
Arginine finger 655..658 2/2 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1241
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D232729at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.