Protein Alignment Mcm5 and Mcm3

DIOPT Version :10

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_032589.1
• Gene: Mcm3 / 17215
• MGIID: 101845
• Length: 812
• Species: Mus musculus
• Alignment Length: 765
• Identity: 228/765 - (29%)
• Similarity: 350/765 - (45%)
• Gaps: 131/765 - (17%)

  Fly    25 INLQAVKKKYKEFIRTFNEENFFY-KYRDTLKRNYLNGRYFLEIEMEDLVGFDETLADKLNKQPT 88
            :.|:..::.|.:|:....::..:. |.|:.:..|    :|.|.:.:.||...:|..|::|.....
Mouse    10 VELREAQRDYLDFLDDEEDQGIYQNKVRELISDN----QYRLIVSVNDLRRKNEKRANRLLNNAF 70

  Fly    89 EHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLSSNANPTNIRQLKSDCVSKLVKIAGIIVAA 153
            |.|..|:.|.::....|.|...:..|..: |.:..|..:...:.|.|.|..:|.:|.:.||:...
Mouse    71 EELVAFQRALKDFVASIDATYAKQYEEFY-IGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKC 134

  Fly   154 SGISAKATRMSIQC-------------LSCSTVIPNLKVNP-------------GLEGYALPRKC 192
            |.:..|..|....|             |:.....|:..|.|             ||..|.
Mouse   135 SLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYK----- 194

  Fly   193 NTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNR 257
                                     |.||:.:||:|:..|.|::||.:.:..|..|.::|.||:|
Mouse   195 -------------------------DHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKVKPGDR 234

  Fly   258 VLIQGIYSIRKVGKPSRRDGREKAV-VGVRAPYM-RVVGITVDSEGAGAISRYSNITSDEEEHFR 320
            :.:.|.|......|.....|..:.| :......| :.:.....::....|.::|.
Mouse   235 IQVVGTYRCLPGKKGCYTSGTFRTVLIACNVKQMSKDIQPAFSADDIAKIKKFSK---------- 289

  Fly   321 RMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKS 385
              ..|.|::|:|::||||||.|...:||||.|:|.||..:.|.:|...|||||:||:|||..|||
Mouse   290 --TRSKDVFEQLARSLAPSIHGHDYVKKAILCLLLGGVERELENGSHIRGDINILLIGDPSVAKS 352

  Fly   386 QLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMRED 450
            |||::|...||.|:.|:|:|||..||||:|..|.:|....:|.|||||||.|||||||||||.:.
Mouse   353 QLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDM 417

  Fly   451 DRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKGE-ENIDFMPTILSRFDMI 514
            ||.||||.|||..::||||||...||:|||||||||.::||:|..|.. |||....::|||||::
Mouse   418 DRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLL 482

  Fly   515 FIVKDIHDESRDITLAKHIINVH--------------LSSNKS--APSEP--------------- 548
            ||:.|..|..:|..::.|::.:|              |.|:..  |..:|
Mouse   483 FIMLDQMDPEQDREISDHVLRMHQYRAPGEQDGDALPLGSSVDILATDDPDFTQDDQQDTRIYEK 547

  Fly   549 -----------AEGEISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKR 602
                       .|..:|.:..|||||..:. ..|.|::.:...:...|..:||   |...:||..
Mouse   548 HDSLLHGTKKKKEKMVSAAFMKKYIHVAKI-IKPTLTQESAAYIAEEYSRLRS---QDSMSSDTA 608

  Fly   603 LSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVS----TLDAAMTGSLAGAEGFT 663
            .:.|:|.|.||.:||::.:.||.|:......:...||:.|.|.:    .|:.......|..:...
Mouse   609 RTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKASEDESD 673

  Fly   664 TEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQKYEERTVMKVIHT 713
            .|:::|......:|.::|....::..|.....||    .|..|.|..:||
Mouse   674 LEDEEEKSQEDTEQKRKRRKTHAKDGESYDPYDF----SEAETQMPQVHT 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	20/94 (21%)
		MCM	128..648	CDD:214631	192/594 (32%)
Mcm3	NP_032589.1	MCM_N	16..104	CDD:464206	20/92 (22%)
		MCM	109..654	CDD:214631	192/590 (33%)
		Arginine finger	477..480		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	664..744		13/60 (22%)