DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm5 and mcm-4

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_490962.1	Gene:	mcm-4 / 171793	WormBaseID:	WBGene00003156	Length:	823	Species:	Caenorhabditis elegans

Alignment Length:	790	Identity:	244/790 - (30%)
Similarity:	379/790 - (47%)	Gaps:	162/790 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DNFGGDNQQ------DAQINLQAVKKKYKEFIRTF------NEENFFYKYRDTLKRNYLNGRYFL 65
            |...||:.|      ..:|.:..|::.:::|:.||      .:||....:.:.|....:|..|::
Worm    94 DEMAGDDGQPRLYVWGTRICVADVQRSFRDFLTTFKISQLAEDENMMTGHDEALHEIDVNHPYYM 158

  Fly    66 E--------------IEMEDLVGFDETLADKLNKQPTEHL--------EIFEEAAREVADEITAP 108
            |              :.::.|..|.|.|..|:...|.:.:        |:|.|.......:....
Worm   159 ERLLECNDAEVTHINLNLKHLNAFSEALYRKVIAYPADVIPYLDIVVNEVFAERFNRTLAQSIEL 223

  Fly   109 RPEHEEHMHDIQILLSSNANPT-NIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCST 172
            ||              .||..| |:|.|..:.|.:|:.|:|::...|.:..:......||..|:.
Worm   224 RP--------------FNAQKTRNMRGLNPNDVDQLITISGMVTRTSSLIPEMRSGYFQCAVCAF 274

  Fly   173 VIPNLKVNPG-LEGYALPRKC-NTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGE 235
            .|.: :|:.| :|...:...| ||.      |    |.::.::...:|.|.:||||.||.:|.||
Worm   275 GIES-EVDKGRIEEPVVCTNCSNTH------C----FQLVHNRSVFLDKQVVKLQESPDDMPSGE 328

  Fly   236 IPRHLQLFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVVGITVDSE 300
            .|..:.::...||.|.|.||:|:.:.||:                          |..|:.|:.:
Worm   329 TPHTVSVYAHGSLVESVQPGDRITVTGIF--------------------------RATGMKVNPK 367

  Fly   301 GAGAISRYSNITSDEEEHFRRMAAS------------------------GDIYERLSQSLAPSIF 341
            .....|.|.  ||.:..|||:|..|                        .||.:.|:||:||||:
Worm   368 QRALASVYR--TSIDALHFRKMDTSRLHQDNGETITEERIQQIIELSKRPDIMDALAQSIAPSIY 430

  Fly   342 GSRDIKKAITCMLFGGSRK--RLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGK 404
            ...|:|:.:.|:||||:||  ...:....|.:||:||.|||||:|||:|::|.::.|.:.|||||
Worm   431 EHDDVKRGLLCLLFGGTRKDDETTNKTKLRSEINILLCGDPGTSKSQMLQYVYRLLPRSQYTSGK 495

  Fly   405 GSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKA 469
            ||||.||||||.:|..|:..|::.||:||||.||.||||||||.|..|..:||.|||||:|||||
Worm   496 GSSAVGLTASVSRDADTKQLVLQTGALVLADNGVCCIDEFDKMNESARSVLHEVMEQQTLSIAKA 560

  Fly   470 GITTTLNSRCSVLAAANSIFGRWDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHI 533
            ||...||:|.|||||||.:..:|:..|. .|||....|:|||||:||::.|..||.:|..|..|:
Worm   561 GIICQLNARASVLAAANPVDSKWNRNKTIVENITLPHTLLSRFDLIFLIVDAQDEMQDRRLGNHL 625

  Fly   534 INVHLSSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKA 598
            ::::..::.:  .|..| .:.::..:.||.|.:.:..|:|||.|.:.:..:|:.||       ||
Worm   626 VSLYFENDGN--QEKTE-HVDMNLLRDYIAYAKANIHPKLSEEASQFIIEKYLFMR-------KA 680

  Fly   599 SDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQ----------------VST 647
            ..:...|....||||::||:||:.|||||....:.:.|.:|..|::                |:.
Worm   681 GAQHGQITAYPRQLESLIRLSEAHAKIRLSQEVSVDDVEKAFTLWREALKQSAVDPSTGRVDVAI 745

  Fly   648 LDAAMTGS---------------LAGAEGFTTEEDQ-ETLNRIEKQLKRRF---AIGSQVSEQNI 693
            |.:.|:.|               |..|:||.|.:.. .||...:|..:|..   ||.....:::|
Worm   746 LASGMSASGRKAVEAMCEAVLKQLKTAKGFVTSKALFHTLKSADKTCQREVFDEAINELSKKESI 810

  Fly   694 LQDFLRQKYE 703
            .:...|.:::
Worm   811 ARSGDRIRFQ 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	20/120 (17%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	200/565 (35%)
mcm-4	NP_490962.1	MCM_N	121..226	CDD:317013	20/118 (17%)
mcm-4	NP_490962.1	MCM_OB	230..730	CDD:330264	199/548 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820