Protein Alignment Mcm5 and Mcm7

DIOPT Version :10

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: XP_315815.3
• Gene: Mcm7 / 1276468
• VectorBaseID: AGAMI1_002838
• Length: 717
• Species: Anopheles gambiae
• Alignment Length: 747
• Identity: 240/747 - (32%)
• Similarity: 372/747 - (49%)
• Gaps: 109/747 - (14%)

  Fly    33 KYKEFIRTFNEENFFYKYRDTLKRNYLNGRYF----------LEIEMEDLVGFDETLADKLNKQP 87
            |.||.|::|..|  ||:..|..|:|::..|..          |.::::|:..:.:.||:.:....
Mosquito     7 KDKETIKSFLAE--FYREEDDGKKNFVYARQLTKIAHREQIQLVVDLDDVASYKDELAEAMQVNS 69

  Fly    88 TEHLEIFEEAA---------REVADEIT----------------APRPEHEEH---------MHD 118
            ..::::|.:|.         |||.::.|                .|....:..         .:|
Mosquito    70 RRYVKLFSDAVFELLPSYKEREVTNKDTLDIFIEHRLLMQGRLHGPNDTRDARNAIPMELIKRYD 134

  Fly   119 IQILLSSNANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCST----VIPNLKV 179
            :.....|.|...:||.:|:|.:.|||.:.||:...:.:....|..:..|..|.:    .:.::..
Mosquito   135 VYFKAPSMAKAVSIRDVKADSIGKLVAVRGIVTRCTEVKPMMTVATYTCDRCGSETYQPVTSMSF 199

  Fly   180 NPGLEGYALPRK-CNTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLF 243
            .|.:|   .|.: |...:||      ...::.....|.|.||.:|:||..|.||.|.|||.|.:.
Mosquito   200 KPAIE---CPSEDCRVNKAG------GRLYLQTRGSKFVKFQEIKIQEHSDQVPVGHIPRSLTVM 255

  Fly   244 CDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYM----RVVGITVDSEGAGA 304
            |.........||:.|:|.||:      .|.::.|....|.|:.:...    |:|.:....:|
Mosquito   256 CRGETTRCAQPGDHVIITGIF------LPIQKTGFRAVVSGLLSETFVDAHRIVCLNKSDDG--- 311

  Fly   305 ISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRR 369
             ...:.:|.:|.:..    |..|.|.|::.||||.|:|..|:|||:..:|.||. .|.|||:..|
Mosquito   312 -ELNNELTQEELDEL----AKDDFYTRIASSLAPEIYGHLDVKKALLLLLVGGV-DRSPDGMKIR 370

  Fly   370 GDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLA 434
            |:||:.|:||||.||||||.:::::|..:.||:|:|||..||||:|||||.|...|:||||:|||
Mosquito   371 GNINICLMGDPGVAKSQLLGYIDRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMVLEGGALVLA 435

  Fly   435 DGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKG-E 498
            |.||.||||||||.::|||:|||.|||||||||||||.|.||:|.|:|||||..:||::..:. |
Mosquito   436 DQGVCCIDEFDKMADEDRVSIHEVMEQQTISIAKAGIMTCLNARVSILAAANPAYGRYNPRRTIE 500

  Fly   499 ENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGEISLSTFKKYIH 563
            :||.....:|||||::::::|..|...|:.|||||..|| |..|..||...  .:.::..::||.
Mosquito   501 QNIQLPAALLSRFDLLWLIQDKADRDNDLRLAKHITYVH-SHGKQPPSRIK--TLDMTLIRRYIA 562

  Fly   564 YCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQ 628
            .|:... |.::....:.:.:.||.:|      .:|.:.|.....:.|.|..::|:|.:||::||.
Mosquito   563 LCKRKI-PVITPELTDYIVNAYVELR------REARNSRDMTFTSARNLLGILRLSTALARLRLA 620

  Fly   629 PFATDEHVNEALRLFQVSTLDAAMTGSLAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNI 693
            .....:.|.|||||..:|      ..||:..|...|.. |.|.::|...::........|...:|
Mosquito   621 DTVEKDDVKEALRLLAMS------KDSLSQTEHRDTHV-QNTSDKIFALVRELAGESKTVKVADI 678

  Fly   694 LQ------------DFLRQKYEERTVMKVIHT 713
            ::            |...:.|||..|.:|..|
Mosquito   679 MERCTTKGYKPDEVDECIETYEELNVWQVNQT 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	24/135 (18%)
		MCM	128..648	CDD:214631	198/529 (37%)
Mcm7	XP_315815.3	None