Protein Alignment Mcm5 and mcm8

DIOPT Version :9

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: XP_002665161.2
• Gene: mcm8 / 100333576
• ZFINID: ZDB-GENE-120927-1
• Length: 852
• Species: Danio rerio
• Alignment Length: 781
• Identity: 224/781 - (28%)
• Similarity: 369/781 - (47%)
• Gaps: 153/781 - (19%)

  Fly     9 VFFSDNFGGDNQQDAQINLQAVKKKYKEFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIEMEDLV 73
            ::||:.|             .....|.|.|:.|  |.:|....|...::.:..:..:.::.:||:
Zfish    92 LYFSEGF-------------VESSPYVEKIKVF--EQYFTSQIDLYDKDEIERKGSILVDYKDLL 141

  Fly    74 GFDET------LADKLNKQPTEHLEIFEEAAREVADEITAPRPEH-------EEHMHDIQILLS- 124
            ...:.      ||..|.:.|.:.|:....|..:|   :|.....|       ||....|:.:::
Zfish   142 SNKQVSHSLPDLARDLKEMPEKILDCLGVAIHQV---LTLDLERHAAELQGQEELPAGIRPIINI 203

  Fly   125 -------SNANP-TNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSC----STVIPNL 177
                   .|..| |.::.|:::...|.|.|.|.:|..|.|.....:::..|.||    |..:|:.
Zfish   204 PHISARLYNYEPLTPLKSLRANLYGKFVVIRGTVVRVSNIKPLCMKLAFVCNSCGDTQSVTLPDG 268

  Fly   178 KVNPGLEGYALPRKC-NTEQAGRPKCP--LDPFFIMPDKCKCVDFQTLKLQEL--PDFVPQGEIP 237
            |       |.:|.|| .:|..||...|  ..||.:      .||:||:|:|||  .|....|.||
Zfish   269 K-------YTMPTKCLQSECRGRSFTPNRSSPFTL------TVDWQTIKVQELMSGDQRESGRIP 320

  Fly   238 RHLQLFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVVGIT------ 296
            |.::....:.|.:..|||:.|.|.|:..:.. .:.|.|:.::|.:..:   |::...::
Zfish   321 RTIECELTQDLVDSCVPGDMVTITGVIKVSN-EEGSTRNKKDKCMFLL---YIQANSVSNSKGQK 381

  Fly   297 ----VDSEGAGAISRYS--NITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLF 355
                .:|||.|....:|  ::.:.:|     :.|..|:::.:..||.|.|:|...:|..:...||
Zfish   382 SKAVSESEGQGPSVEFSIKDLYAIQE-----IQAQEDLFKLIVNSLCPVIYGHLLVKAGLALALF 441

  Fly   356 GGSRKRLPD--GLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKD 418
            ||.:|.:.|  .:..|||.::|::||||..|||:|:.|..|||..||..|..::.:|||.|:.:|
Zfish   442 GGCQKYVDDKNRIPIRGDPHMLIVGDPGLGKSQMLQAVCNVAPRGVYVCGNTTTTSGLTVSLSRD 506

  Fly   419 PQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLA 483
            ..:.::.:|.||:||.|.|:.||||||||....: |:.||||||:||:|||||..||.:|.|::|
Zfish   507 SGSGDYALEAGALVLGDQGICCIDEFDKMGSQHQ-ALLEAMEQQSISLAKAGIVCTLPARTSIIA 570

  Fly   484 AANSIFGRWDDTKGE---ENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHII----------- 534
            |||.:.|.::  ||:   ||:.....:|||||::||:.|..:|..|..|::|::
Zfish   571 AANPVGGHYN--KGKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVMAMRAGKSGAVS 633

  Fly   535 -------NVHLSS---------------NKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRLSEAA 577
                   |.|.||               .|..|.| |...|.....:||:.|.|.:..|.||..|
Zfish   634 GAAATRFNTHESSISILEVSSEKPLADTLKLVPGE-AFDPIPHQLLRKYVGYARHYVHPTLSAEA 697

  Fly   578 GEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRL 642
            .:.|:..|:.:|    :|.:.:|   |.|||.||||::||::|:.|::.|:..||.....:.:.:
Zfish   698 AQVLQDFYLELR----KQNQTAD---STPITTRQLESLIRLTEARARVELREKATQSDAEDVVEI 755

  Fly   643 FQVSTLDAAMTGSLAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLR--QKYEER 705
            .:.|..|              |..|:  ..|::..   |..:||.:|.::.::.|:.  .|..||
Zfish   756 MKHSLTD--------------TYSDE--FGRLDFD---RSQLGSGMSNRSKVKKFVSALNKLAER 801

  Fly   706 T 706
            |
Zfish   802 T 802

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	21/105 (20%)
		MCM	128..648	CDD:214631	186/579 (32%)
mcm8	XP_002665161.2	Mcm2	110..801	CDD:224162	215/747 (29%)
		MCM_N	111..235	CDD:291233	25/128 (20%)
		AAA	451..605	CDD:99707	72/156 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820