DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art1 and PRMT9

DIOPT Version :9

Sequence 1:	NP_650017.1	Gene:	Art1 / 41295	FlyBaseID:	FBgn0037834	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_612373.2	Gene:	PRMT9 / 90826	HGNCID:	25099	Length:	845	Species:	Homo sapiens

Alignment Length:	364	Identity:	90/364 - (24%)
Similarity:	152/364 - (41%)	Gaps:	63/364 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ESATGITPNSNANSNNVAKKL-------PAEGSTGDNPNANADEMTSRDYYFDSYAHFGI---HE 67
            |.|..:.|:.....|::.:.|       .|.|........|.|...:::.:: ..|::.:   |.
Human    91 EQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFSDAKENFY-RVANWLVERWHF 154

  Fly    68 EMLKDEVRTVTYRNAMYHNKHLFQGKTVLDVGCGTGILSMFAAKAGAAQVIAVDCS-NIIEFARQ 131
            .||.|..|...| ||..........|:|||:|.|||||||||.||||..|.|.:.| .:.|.|..
Human   155 IMLNDTKRNTIY-NAAIQKAVCLGSKSVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACD 218

  Fly   132 VVIDNNLQDVITVVKGKIEEIELPNGI-EGVDIIISEWMGYCLFYESMLDTVLYARDKWL----- 190
            ||..|.::..|.::..|..:||:|..| |.|.::::|.:...||.|.:::::::|.:..|
Human   219 VVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVDAGLFGEGIVESLIHAWEHLLLQPKT 283

  Fly   191 -------KKDGMMFPDRGTLYITAIEDRQYKDEKINWWDDVYGFDMSCIRKVAVTEPLVDVVDPK 248
                   :|.|.:.|....::..|:|..:.:........|:.|..:.  ..|....|....||.:
Human   284 KGESANCEKYGKVIPASAVIFGMAVECAEIRRHHRVGIKDIAGIHLP--TNVKFQSPAYSSVDTE 346

  Fly   249 QVVS-----------------TSCM-VKEVDLYTVQ--------KADLNFSSKFSLCIKRNDFVQ 287
            :.:.                 |.|. :..||...:|        |.|     |..:.:.:...:.
Human   347 ETIEPYTTEKMSRVPGGYLALTECFEIMTVDFNNLQELKSLATKKPD-----KIGIPVIKEGILD 406

  Fly   288 ALVTYFNIEFTKCHKRLGFSTSPDSTYTHWKQTVFYLDD 326
            |::.:|.::....|   ..|||| |..|.|:|.|:.:.|
Human   407 AIMVWFVLQLDDEH---SLSTSP-SEETCWEQAVYPVQD 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art1	NP_650017.1	AdoMet_MTases	94..194	CDD:100107	40/113 (35%)
PRMT9	NP_612373.2	TPR 1	25..58
		TPR	<39..144	CDD:223533	9/53 (17%)
		TPR 2	67..100		3/8 (38%)
		TPR repeat	68..95	CDD:276809	2/3 (67%)
		TPR repeat	100..130	CDD:276809	4/29 (14%)
		TPR 3	101..134		5/32 (16%)
		AdoMet_MTases	148..>303	CDD:327401	51/155 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810