DRSC/TRiP Functional Genomics Resources

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Protein Alignment Art1 and Carm1

DIOPT Version :10

Sequence 1:NP_650017.1 Gene:Art1 / 41295 FlyBaseID:FBgn0037834 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_067506.2 Gene:Carm1 / 59035 MGIID:1913208 Length:608 Species:Mus musculus


Alignment Length:364 Identity:126/364 - (34%)
Similarity:190/364 - (52%) Gaps:30/364 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 TPNSNANSNNVAKKLPAEGSTGD-NPNANADEMTSRDYYFDSYAHFGIHEEMLKDEVRTVTYRNA 82
            ||:...:..|:.|  ...|.|.: :..:...|.:|...||..|.:....:.|::|.|||.||:.|
Mouse   114 TPHDFCSFYNILK--TCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRA 176

  Fly    83 MYHNKHLFQGKTVLDVGCGTGILSMFAAKAGAAQVIAVDCSNIIEFARQVVIDNNLQDVITVVKG 147
            :..|...|:.|.|||||||:||||.|||:|||.::.||:.|.:.:.|..:|..|||.|.|.|:.|
Mouse   177 ILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPG 241

  Fly   148 KIEEIELPNGIEGVDIIISEWMGYCLFYESMLDTVLYARDKWLKKDGMMFPDRGTLYITAIEDRQ 212
            |:||:.||   |.|||||||.|||.||.|.||::.|:|: |:||..|.|||..|.:::....|.|
Mouse   242 KVEEVSLP---EQVDIIISEPMGYMLFNERMLESYLHAK-KYLKPSGNMFPTIGDVHLAPFTDEQ 302

  Fly   213 -YKDE--KINWW--DDVYGFDMSCIRKVAVTE----PLVDVVDPKQVVSTSCM-------VKEVD 261
             |.::  |.|:|  ...:|.|:|.:|..||.|    |:||..|.:.:::.|..       .||.|
Mouse   303 LYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGD 367

  Fly   262 LYTVQKADLNFSSKFSLCIKRNDFVQALVTYFNIEFTKCHKRLGFSTSPDSTYTHWKQTVFYLDD 326
            |:.::       ..|...:..:..|..|..:|::.|......:..||:|....|||.|.......
Mouse   368 LHRIE-------IPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQS 425

  Fly   327 HMTAKKNEEITGTFQMKPNERNNRDLDFVIDINFKGELS 365
            .:.||..:.::||..:..|:|.:.|:..|..::..|..|
Mouse   426 PLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKS 464

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Art1NP_650017.1 COG4076 66..>231 CDD:443253 79/169 (47%)
Carm1NP_067506.2 Interaction with C9orf72. /evidence=ECO:0000269|PubMed:30366907 28..139 6/26 (23%)
CARM1 35..139 CDD:402914 6/26 (23%)
COG4076 160..347 CDD:443253 88/190 (46%)
Required for nuclear translocation. /evidence=ECO:0000269|PubMed:30366907 347..380 6/39 (15%)
Transactivation domain. /evidence=ECO:0000269|PubMed:11701890 500..608
Blue background indicates that the domain is not in the aligned region.

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