DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art1 and prmt3

DIOPT Version :9

Sequence 1:	NP_650017.1	Gene:	Art1 / 41295	FlyBaseID:	FBgn0037834	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001017655.1	Gene:	prmt3 / 550348	ZFINID:	ZDB-GENE-041105-1	Length:	512	Species:	Danio rerio

Alignment Length:	403	Identity:	175/403 - (43%)
Similarity:	248/403 - (61%)	Gaps:	45/403 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IPMEAAVESATGITPNSNANSNNVAK-------------------KLPAEG-----STGDNPNAN 46
            |.:|...|::.|:..:|.|:..||..                   ||.|:|     .|...|..:
Zfish   123 IDVEELREASGGMGSSSAADQVNVEDRVQRAEEALARAMQDMHKLKLLAQGLVLNADTSHGPTCS 187

  Fly    47 A-------DEMTSRDYYFDSYAHFGIHEEMLKDEVRTVTYRNAMYHNKHLFQGKTVLDVGCGTGI 104
            .       ||   .:.||.||.|:.||||||||:|||.:||:.||.|..:|:.|.||||||||||
Zfish   188 GAIAELREDE---DEAYFSSYGHYSIHEEMLKDKVRTESYRDFMYRNMDVFKDKVVLDVGCGTGI 249

  Fly   105 LSMFAAKAGAAQVIAVDCSNIIEFARQVVIDNNLQDVITVVKGKIEEIELPNGIEGVDIIISEWM 169
            ||||||||||.:|:|||.|.||..|..:|..|||:|.||::||:||||:||  :|.|||||||||
Zfish   250 LSMFAAKAGAKKVVAVDQSEIIYQAMDIVRSNNLEDTITLIKGRIEEIDLP--VEKVDIIISEWM 312

  Fly   170 GYCLFYESMLDTVLYARDKWLKKDGMMFPDRGTLYITAIEDRQYKDEKINWWDDVYGFDMSCIRK 234
            ||.|.:.||||:||||||::|..||::||||.::.:.|:.|.|..:::|.:|:|||||.|:|::|
Zfish   313 GYFLLFGSMLDSVLYARDRYLADDGLVFPDRCSISLAAVGDTQKHNDRIAFWEDVYGFKMTCMKK 377

  Fly   235 VAVTEPLVDVVDPKQVVSTSCMVKEVDLYTVQKADLNFSSKFSLCIKRNDFVQALVTYFNIEFTK 299
            ..:.|.:|:|:.|:.|:|.|.::|.:|..:|..::|.||..|.|.|..:.|..|:|.||:|.|.|
Zfish   378 AVIPEAVVEVLKPETVISESAVIKTIDCGSVSVSELEFSVDFILKITASSFCTAIVGYFDIFFHK 442

  Fly   300 -CHKRLGFSTSPDSTYTHWKQTVFYLDDHMTAKKNEEITGTFQMKPNERNNRDLDFVIDINFKGE 363
             |..::.|||:|:.|.||||||||.|:..:..|..|::.|...::.|.::.|.|  :|.:|..|
Zfish   443 SCGNKVMFSTAPNCTKTHWKQTVFLLESPVAVKAGEDLPGHISVRKNRKDPRAL--LITLNIAG- 504

  Fly   364 LSQIQESNTYRMR 376
                 ...||.::
Zfish   505 -----HKQTYSLQ 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art1	NP_650017.1	AdoMet_MTases	94..194	CDD:100107	67/99 (68%)
prmt3	NP_001017655.1	zf-C2H2_2	39..>86	CDD:289522
prmt3	NP_001017655.1	Methyltransf_18	236..340	CDD:289607	70/105 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D432852at33208
OrthoFinder	1	1.000	-	-		FOG0000206
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820