DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Art1 and PRMT2

DIOPT Version :9

Sequence 1:	NP_650017.1	Gene:	Art1 / 41295	FlyBaseID:	FBgn0037834	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001526.2	Gene:	PRMT2 / 3275	HGNCID:	5186	Length:	433	Species:	Homo sapiens

Alignment Length:	338	Identity:	113/338 - (33%)
Similarity:	183/338 - (54%)	Gaps:	38/338 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SNNVAKKLPAEGSTGDNPNANADEMTSRD-----YYFDSYAHFGIHEEMLKDEVRTVTYRNAMYH 85
            :|:|.|              :.||....|     .||.||....:|.|||.|:.||..|.:.:..
Human    81 ANHVGK--------------HVDEYDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQ 131

  Fly    86 NKHLFQGKTVLDVGCGTGILSMFAAK-AGAAQVIAVDCSNIIEFARQVVIDNNLQDVITVVKGKI 149
            ||.....|.:|||||||||:|:|.|. |....|.||:.|.:.:...|:|:.|...|:|||.:.|:
Human   132 NKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLVLQNGFADIITVYQQKV 196

  Fly   150 EEIELPNGIEGVDIIISEWMGYCLFYESMLDTVLYARDKWLKKDGMMFPDRGTLYITAIE-DRQY 213
            |::.||   |.||:::|||||.||.:|.|::::|||||.|||:||:::|....|::.... |:.|
Human   197 EDVVLP---EKVDVLVSEWMGTCLLFEFMIESILYARDAWLKEDGVIWPTMAALHLVPCSADKDY 258

  Fly   214 KDEKINWWDDVYGFDMSCIRKVAVTE----PLVD-VVDPKQVVSTSCMVKEVDLYTVQKADL-NF 272
            : .|:.:||:.|.|::|.::.:||.|    |..: ::.|:..:|..|.:.::|:.|||.:|| ..
Human   259 R-SKVLFWDNAYEFNLSALKSLAVKEFFSKPKYNHILKPEDCLSEPCTILQLDMRTVQISDLETL 322

  Fly   273 SSKFSLCIKRNDFVQALVTYFNIEFTKCHKRLG-----FSTSPDSTYTHWKQTVFYLDDHMTAKK 332
            ..:....|::...:.....:|::.|....:  |     .||.|....||||||:|.:||.:....
Human   323 RGELRFDIRKAGTLHGFTAWFSVHFQSLQE--GQPPQVLSTGPFHPTTHWKQTLFMMDDPVPVHT 385

  Fly   333 NEEITGTFQMKPN 345
            .:.:||:..::.|
Human   386 GDVVTGSVVLQRN 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art1	NP_650017.1	AdoMet_MTases	94..194	CDD:100107	48/100 (48%)
PRMT2	NP_001526.2	Interaction with ESR1	1..277		81/213 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SH3_PRMT2	34..86	CDD:212740	2/4 (50%)
		Interaction with RB1. /evidence=ECO:0000250	83..207		50/140 (36%)
		AdoMet_MTases	110..>169	CDD:302624	27/58 (47%)
		Interaction with ESR1	133..275		61/145 (42%)
		AdoMet_MTases	141..241	CDD:100107	50/102 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	1	1.000	-	-		FOG0000206
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920