DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art1 and METTL7B

DIOPT Version :9

Sequence 1:	NP_650017.1	Gene:	Art1 / 41295	FlyBaseID:	FBgn0037834	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_689850.2	Gene:	METTL7B / 196410	HGNCID:	28276	Length:	244	Species:	Homo sapiens

Alignment Length:	209	Identity:	45/209 - (21%)
Similarity:	75/209 - (35%)	Gaps:	59/209 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ITPNSNANSNNVAKKL--PAEGSTGDNPNANADEM---TSRDYYF----------DSYAHFGIHE 67
            :||.||....:..::|  ..:|.||.:......|:   |..::.|          |...||   |
Human    43 LTPKSNRKMESKKRELFSQIKGLTGASGKVALLELGCGTGANFQFYPPGCRVTCLDPNPHF---E 104

  Fly    68 EMLKDEVRTVTYRNAMYHNKHLFQGKTVLDVGCGTGILSMFAAKAGAAQVIA---VDCSNIIEFA 129
            :.|         ..:|..|:||...:.|:..|     ..|.....|:..|:.   |.||  ::..
Human   105 KFL---------TKSMAENRHLQYERFVVAPG-----EDMRQLADGSMDVVVCTLVLCS--VQSP 153

  Fly   130 RQVVIDNNLQDVITVVKGKIEEIELPNGI----EGVDIIISEW--MGYCLF---YESMLDTVLYA 185
            |:|     ||:|..|::        |.|:    |.|......|  |...:|   ::.:.|.....
Human   154 RKV-----LQEVRRVLR--------PGGVLFFWEHVAEPYGSWAFMWQQVFEPTWKHIGDGCCLT 205

  Fly   186 RDKWLKKDGMMFPD 199
            |:.|...:...|.:
Human   206 RETWKDLENAQFSE 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art1	NP_650017.1	AdoMet_MTases	94..194	CDD:100107	24/111 (22%)
METTL7B	NP_689850.2	Methyltransf_11	75..172	CDD:369777	28/128 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900