DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art1 and CARM1

DIOPT Version :9

Sequence 1:	NP_650017.1	Gene:	Art1 / 41295	FlyBaseID:	FBgn0037834	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_954592.1	Gene:	CARM1 / 10498	HGNCID:	23393	Length:	608	Species:	Homo sapiens

Alignment Length:	364	Identity:	127/364 - (34%)
Similarity:	190/364 - (52%)	Gaps:	30/364 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 TPNSNANSNNVAKKLPAEGSTGD-NPNANADEMTSRDYYFDSYAHFGIHEEMLKDEVRTVTYRNA 82
            |||...:..|:.|  ...|.|.: :..:...|.:|...||..|.:....:.|::|.|||.||:.|
Human   113 TPNDFCSFYNILK--TCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRA 175

  Fly    83 MYHNKHLFQGKTVLDVGCGTGILSMFAAKAGAAQVIAVDCSNIIEFARQVVIDNNLQDVITVVKG 147
            :..|...|:.|.|||||||:||||.|||:|||.::.||:.|.:.:.|..:|..|||.|.|.|:.|
Human   176 ILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPG 240

  Fly   148 KIEEIELPNGIEGVDIIISEWMGYCLFYESMLDTVLYARDKWLKKDGMMFPDRGTLYITAIEDRQ 212
            |:||:.||   |.|||||||.|||.||.|.||::.|:|: |:||..|.|||..|.:::....|.|
Human   241 KVEEVSLP---EQVDIIISEPMGYMLFNERMLESYLHAK-KYLKPSGNMFPTIGDVHLAPFTDEQ 301

  Fly   213 -YKDE--KINWW--DDVYGFDMSCIRKVAVTE----PLVDVVDPKQVVSTSCM-------VKEVD 261
             |.::  |.|:|  ...:|.|:|.:|..||.|    |:||..|.:.:::.|..       .||.|
Human   302 LYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGD 366

  Fly   262 LYTVQKADLNFSSKFSLCIKRNDFVQALVTYFNIEFTKCHKRLGFSTSPDSTYTHWKQTVFYLDD 326
            |:.::       ..|...:..:..|..|..:|::.|......:..||:|....|||.|.......
Human   367 LHRIE-------IPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQS 424

  Fly   327 HMTAKKNEEITGTFQMKPNERNNRDLDFVIDINFKGELS 365
            .:.||..:.::||..:..|:|.:.|:..|..::..|..|
Human   425 PLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKS 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art1	NP_650017.1	AdoMet_MTases	94..194	CDD:100107	55/99 (56%)
CARM1	NP_954592.1	CARM1	34..138	CDD:288395	7/26 (27%)
		PRMT5	<172..435	CDD:282971	101/273 (37%)
		Methyltransf_18	184..283	CDD:289607	56/102 (55%)
		Transactivation domain. /evidence=ECO:0000250	499..608
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820