DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbp1 and PSPC1

DIOPT Version :9

Sequence 1:	NP_731510.1	Gene:	Rbp1 / 41294	FlyBaseID:	FBgn0260944	Length:	144	Species:	Drosophila melanogaster
Sequence 2:	NP_001035879.1	Gene:	PSPC1 / 55269	HGNCID:	20320	Length:	523	Species:	Homo sapiens

Alignment Length:	203	Identity:	41/203 - (20%)
Similarity:	70/203 - (34%)	Gaps:	62/203 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PRYREWDLACKVYVGNLGSSASKHEIEGAFAKYGPLRNVWVARNPPGFAFVEFEDRRDAEDATRA 66
            |..:.:...|:::||||.:..::.:.:..|.:||....|::.|: .||.|:..|.|..||.|...
Human    73 PGEKTYTQRCRLFVGNLPTDITEEDFKRLFERYGEPSEVFINRD-RGFGFIRLESRTLAEIAKAE 136

  Fly    67 LDGTRCCGTRIRVEMSSGRS-----------------------------------RDRRRGEG-- 94
            ||||......:|:..::..:                                   |.|..|:|
Human   137 LDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRATGKGFV 201

  Fly    95 ---------GSSGRSGSGRYRITPSARTTSTATSSFYN---------INNLQQ------QPSSQP 135
                     .:..|.|.|.:.:|.:.|.........::         :...||      ||....
Human   202 EFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEKLMQKTQQYHKEREQPPRFA 266

  Fly   136 QPATFNLQ 143
            ||.||..:
Human   267 QPGTFEFE 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp1	NP_731510.1	RRM_SRSF3_like	12..81	CDD:409808	22/68 (32%)
PSPC1	NP_001035879.1	RRM1_PSP1	81..151	CDD:241030	23/70 (33%)
		Sufficient for paraspeckles localization	125..358		27/150 (18%)
		RRM2_PSP1	157..236	CDD:241033	9/78 (12%)
		NOPS_PSPC1	227..320	CDD:240584	9/48 (19%)
		Sufficient for perinucleolar caps localization and interaction with NONO. /evidence=ECO:0000269\|PubMed:16148043	231..358		8/44 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	460..523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910