DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIFbeta and gtf-2F2

DIOPT Version :9

Sequence 1:	NP_524305.2	Gene:	TfIIFbeta / 41290	FlyBaseID:	FBgn0010421	Length:	277	Species:	Drosophila melanogaster
Sequence 2:	NP_741661.1	Gene:	gtf-2F2 / 180243	WormBaseID:	WBGene00012694	Length:	263	Species:	Caenorhabditis elegans

Alignment Length:	273	Identity:	100/273 - (36%)
Similarity:	151/273 - (55%)	Gaps:	28/273 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TQIIDKDLDLSNAGRGVWLVKVPKYIAQKWEKAPTNMDVGKLRINKTPGQKAQVSLSLTPAVLAL 73
            |:....|:|...|.|.:||||||:|:::.|:....|: ||||:|.      |||.|.....::..
Worm     4 TKRYSNDVDCELAKRSIWLVKVPRYLSELWDANEGNV-VGKLQIG------AQVELHTAKGLIHP 61

  Fly    74 DPEE---------------KIPTEHILDVSQVTKQTLGVFSHMAPSDGKENSTTSAAQPDNEKLY 123
            .|:|               :||||:...:..|..||:.|.|......|.:      |.....||.
Worm    62 KPKEPTEGSSSTVTQPEASEIPTEYSFILHDVKSQTMSVLSEDKQGLGAD------APIKTGKLA 120

  Fly   124 MEGRIVQKLECRPIADNCYMKLKLESIRKASEPQRRVQPIDKIVQNFKPVKDHAHNIEYRERKKA 188
            :||||::|.||||.|.:.|||:||..|.|.::|::.|:.|:|....||||..||.::...::||.
Worm   121 IEGRIIKKAECRPPATSKYMKMKLAHIVKNTQPKKTVKMIEKAAVKFKPVSVHAEDMIKSKQKKD 185

  Fly   189 EGKKARDDKNAVMDMLFHAFEKHQYYNIKDLVKITNQPISYLKEILKDVCDYNMKNPHKNMWELK 253
            ..|..|.|::.:...||.|||||.:|.::||.::..||:||:||:|:::..||...|||::|.||
Worm   186 GAKTYRADRDVLRGALFKAFEKHSFYRLQDLQQLLQQPVSYVKEVLQEIAVYNTAPPHKSLWCLK 250

  Fly   254 KEYRHYKTEEKKE 266
            .||.:||...:.|
Worm   251 PEYCNYKVNAQSE 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIFbeta	NP_524305.2	TFIIF_beta	20..253	CDD:280438	90/247 (36%)
gtf-2F2	NP_741661.1	TFIIF_beta	16..250	CDD:280438	90/246 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165688
Domainoid	1	1.000	72	1.000	Domainoid score	I6126
eggNOG	1	0.900	-	-		E1_COG5090
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37884
Inparanoid	1	1.050	173	1.000	Inparanoid score	I2733
Isobase	1	0.950	-	0	Normalized mean entropy	S2504
OMA	1	1.010	-	-		QHG55375
OrthoDB	1	1.010	-	-		D1496393at2759
OrthoFinder	1	1.000	-	-		FOG0002863
OrthoInspector	1	1.000	-	-		oto18973
orthoMCL	1	0.900	-	-		OOG6_102568
Panther	1	1.100	-	-	LDO	PTHR10445
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1466
SonicParanoid	1	1.000	-	-		X3816
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750