DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cap-H2 and Ncaph2

DIOPT Version :9

Sequence 1:	NP_650014.2	Gene:	Cap-H2 / 41289	FlyBaseID:	FBgn0037831	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_001258530.1	Gene:	Ncaph2 / 52683	MGIID:	1289164	Length:	608	Species:	Mus musculus

Alignment Length:	844	Identity:	163/844 - (19%)
Similarity:	276/844 - (32%)	Gaps:	264/844 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 DEQQDLASLVVLLEELSKNTDYSTDLRISLGYYIEELLRHCLGRNDVSRRSAIVAAGSALQYCGK 105
            |.:...|.|:..:.:|:||  :..|:...||.|:|||.:.|:..::.......:.|...:|....
Mouse     3 DVEVRFAHLLQPIRDLTKN--WEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSAC 65

  Fly   106 IYGDRVEYLCQVVEHQIEALLTSELQKETPSGSAAPEKNERRPEETRKRHPKKLTNKEVDPYLLT 170
            :|..:||||..:|...::.:          ||               ||..|:|:        |.
Mouse    66 VYSKKVEYLYSLVYQALDFI----------SG---------------KRRAKQLS--------LV 97

  Fly   171 LEPKRFKTMSDDKRFNAAGFVKC-TRNRTIEYLYQDHTPPNLWKHAPIVDPHNPYDQDEKKQYKM 234
            .|....||::.:        ..| |.|   |:|..|..|.:    ...||..|.....|.
Mouse    98 QEDGSKKTVNSE--------TPCETEN---EFLSLDDFPDS----RANVDLKNDQASSEL----- 142

  Fly   235 FTYHVEHRYNTLLPDIPFERLNLIKEYVHTNQVNTTEILNEHMTTKEYLDEYIALENQMLAARYG 299
                      .::|.:|.       ..|..::|       |..::..|     :.:..:||:|..
Mouse   143 ----------LIIPLLPM-------ALVAPDEV-------EKNSSPLY-----SCQGDILASRKD 178

  Fly   300 AIVTRRRRLVDSAR--FMEDNLDEGLAKKMC-MDKNLPMDTNETVLIDQSLVDENSRSLTTAEST 361
               .|....:.:.|  ||.|.:.      || ::..:|::....           |||....|
Mouse   179 ---FRMNTCMPNPRGCFMLDPVG------MCPVEPVVPVEPYPM-----------SRSQKDPE-- 221

  Fly   362 MGISQAENSTLKSSEVEATLSVSHIENSLSDSQEENPPLSSTLAINESSVLDSTR-----VDPIK 421
                .||...::.|...:.:.|..|      |||.:.|   .|:..|....|...     ::|.:
Mouse   222 ----DAEEQPMEVSRNGSPVPVPDI------SQEPDGP---ALSGGEEDAEDGAEPLEVALEPAE 273

  Fly   422 DLTLDELLLIDSGISMEELSDIQMHTAGQSFDDEGVVLSDLEDQRQ-LSPMLQMVSPSMEAKTLN 485
            ..|..:..::.....:.|         .|...:....|.:..|..| |.|.     .|:|:|...
Mouse   274 PRTSQQSAILPRRYMLRE---------RQGAPEPASRLQETPDPWQSLDPF-----DSLESKVFQ 324

  Fly   486 IIEMDADLIMNVPREVSYPILLNVMGLPIKRLRRKCIFKLPPEF-DLFRQARLPIKREGQQKSPT 549
                                    .|.|         :.:||.. :...|.|   ||:|..|...
Mouse   325 ------------------------KGKP---------YSVPPGVEEAPGQKR---KRKGATKLQD 353

  Fly   550 TPRTVLQIGREAPQNEREPGSPCSLEFDEDLNFLGFRQRRPTFDSGFDIEEPRVSSCVSTIGEVK 614
            ..:..|....|.|...|.                  |::.|||   .|:|       |.....||
Mouse   354 FHKWYLDAYAEHPDGRRA------------------RRKGPTF---ADME-------VLYWKHVK 390

  Fly   615 TELEDEIEANTNNLTDASASDALNENVNDTKESGLGDSLAQELNASTEPNAENNTANSSQLEVTA 679
            .:||...:.....:.:.....| .:::..|:|..|.:|| ::|..:.:...|.        |...
Mouse   391 EQLETLQKLRRRKINERWLPGA-KQDLWPTEEDRLEESL-EDLGVAADDFLEP--------EEYV 445

  Fly   680 TESSGTLSGLETTVDLGMESALVSSVLDLSTEPSAMD-SNIINVTQPDNSDLEISTVQD--QDTL 741
            .|.:|.:.  |...|           ||....|.::. ..::.    .|.:|.|:|.|.  |:|
Mouse   446 EEPAGVMP--EEAAD-----------LDAEAMPESLRYEELVR----RNVELFIATSQKFIQET- 492

  Fly   742 HDEADANDLSAETPNPIADSAVDDCSLIRDWHRRLAPALEAAHERQNFNIKDLGTEILDICKAGN 806
                   :||..               ||||...:.|.|:...:...|:|...|.::.......|
Mouse   493 -------ELSQR---------------IRDWEDTIQPLLQEQEQHVPFDIHIYGDQLASRFPQLN 535

  Fly   807 RTATLADVMADKDPSIMCRYMLASLVLTNHGNVSLDFENRDKSKPIDMSQFRM--HLKSMKRME 868
            .....::::|.:....:||.|||||.|.|...|.:. :.......:|....|:  |.::..|.:
Mouse   536 EWCPFSELVAGQPAFEVCRSMLASLQLANDYTVEIT-QQPGLEAAVDTMSLRLLTHQRAHTRFQ 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cap-H2	NP_650014.2	CNDH2_C	<769..844	CDD:293463	21/74 (28%)
Ncaph2	NP_001258530.1	CNDH2_N	11..123	CDD:283849	35/157 (22%)
		CNDH2_M	147..247	CDD:293474	28/150 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..312		23/135 (17%)
		CNDH2_C	308..590	CDD:293463	79/401 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	325..347		8/33 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2359
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005551
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14324
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2597
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030