Protein Alignment Cap-H2 and Ncaph2

DIOPT Version :10

• Sequence 1: NP_650014.2
• Gene: Cap-H2 / 41289
• FlyBaseID: FBgn0037831
• Length: 960
• Species: Drosophila melanogaster
• Sequence 2: NP_001258530.1
• Gene: Ncaph2 / 52683
• MGIID: 1289164
• Length: 608
• Species: Mus musculus
• Alignment Length: 844
• Identity: 163/844 - (19%)
• Similarity: 276/844 - (32%)
• Gaps: 264/844 - (31%)

  Fly    41 DEQQDLASLVVLLEELSKNTDYSTDLRISLGYYIEELLRHCLGRNDVSRRSAIVAAGSALQYCGK 105
            |.:...|.|:..:.:|:||  :..|:...||.|:|||.:.|:..::.......:.|...:|....
Mouse     3 DVEVRFAHLLQPIRDLTKN--WEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSAC 65

  Fly   106 IYGDRVEYLCQVVEHQIEALLTSELQKETPSGSAAPEKNERRPEETRKRHPKKLTNKEVDPYLLT 170
            :|..:||||..:|...::.:          ||               ||..|:|:        |.
Mouse    66 VYSKKVEYLYSLVYQALDFI----------SG---------------KRRAKQLS--------LV 97

  Fly   171 LEPKRFKTMSDDKRFNAAGFVKC-TRNRTIEYLYQDHTPPNLWKHAPIVDPHNPYDQDEKKQYKM 234
            .|....||::.:        ..| |.|   |:|..|..|.:    ...||..|.....|.
Mouse    98 QEDGSKKTVNSE--------TPCETEN---EFLSLDDFPDS----RANVDLKNDQASSEL----- 142

  Fly   235 FTYHVEHRYNTLLPDIPFERLNLIKEYVHTNQVNTTEILNEHMTTKEYLDEYIALENQMLAARYG 299
                      .::|.:|.       ..|..::|       |..::..|     :.:..:||:|..
Mouse   143 ----------LIIPLLPM-------ALVAPDEV-------EKNSSPLY-----SCQGDILASRKD 178

  Fly   300 AIVTRRRRLVDSAR--FMEDNLDEGLAKKMC-MDKNLPMDTNETVLIDQSLVDENSRSLTTAEST 361
               .|....:.:.|  ||.|.:.      || ::..:|::....           |||....|
Mouse   179 ---FRMNTCMPNPRGCFMLDPVG------MCPVEPVVPVEPYPM-----------SRSQKDPE-- 221

  Fly   362 MGISQAENSTLKSSEVEATLSVSHIENSLSDSQEENPPLSSTLAINESSVLDSTR-----VDPIK 421
                .||...::.|...:.:.|..|      |||.:.|   .|:..|....|...     ::|.:
Mouse   222 ----DAEEQPMEVSRNGSPVPVPDI------SQEPDGP---ALSGGEEDAEDGAEPLEVALEPAE 273

  Fly   422 DLTLDELLLIDSGISMEELSDIQMHTAGQSFDDEGVVLSDLEDQRQ-LSPMLQMVSPSMEAKTLN 485
            ..|..:..::.....:.|         .|...:....|.:..|..| |.|.     .|:|:|...
Mouse   274 PRTSQQSAILPRRYMLRE---------RQGAPEPASRLQETPDPWQSLDPF-----DSLESKVFQ 324

  Fly   486 IIEMDADLIMNVPREVSYPILLNVMGLPIKRLRRKCIFKLPPEF-DLFRQARLPIKREGQQKSPT 549
                                    .|.|         :.:||.. :...|.|   ||:|..|...
Mouse   325 ------------------------KGKP---------YSVPPGVEEAPGQKR---KRKGATKLQD 353

  Fly   550 TPRTVLQIGREAPQNEREPGSPCSLEFDEDLNFLGFRQRRPTFDSGFDIEEPRVSSCVSTIGEVK 614
            ..:..|....|.|...|.                  |::.|||   .|:|       |.....||
Mouse   354 FHKWYLDAYAEHPDGRRA------------------RRKGPTF---ADME-------VLYWKHVK 390

  Fly   615 TELEDEIEANTNNLTDASASDALNENVNDTKESGLGDSLAQELNASTEPNAENNTANSSQLEVTA 679
            .:||...:.....:.:.....| .:::..|:|..|.:|| ::|..:.:...|.        |...
Mouse   391 EQLETLQKLRRRKINERWLPGA-KQDLWPTEEDRLEESL-EDLGVAADDFLEP--------EEYV 445

  Fly   680 TESSGTLSGLETTVDLGMESALVSSVLDLSTEPSAMD-SNIINVTQPDNSDLEISTVQD--QDTL 741
            .|.:|.:.  |...|           ||....|.::. ..::.    .|.:|.|:|.|.  |:|
Mouse   446 EEPAGVMP--EEAAD-----------LDAEAMPESLRYEELVR----RNVELFIATSQKFIQET- 492

  Fly   742 HDEADANDLSAETPNPIADSAVDDCSLIRDWHRRLAPALEAAHERQNFNIKDLGTEILDICKAGN 806
                   :||..               ||||...:.|.|:...:...|:|...|.::.......|
Mouse   493 -------ELSQR---------------IRDWEDTIQPLLQEQEQHVPFDIHIYGDQLASRFPQLN 535

  Fly   807 RTATLADVMADKDPSIMCRYMLASLVLTNHGNVSLDFENRDKSKPIDMSQFRM--HLKSMKRME 868
            .....::::|.:....:||.|||||.|.|...|.:. :.......:|....|:  |.::..|.:
Mouse   536 EWCPFSELVAGQPAFEVCRSMLASLQLANDYTVEIT-QQPGLEAAVDTMSLRLLTHQRAHTRFQ 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cap-H2	NP_650014.2	CNDH2_C	<769..862	CDD:465283	24/94 (26%)
Ncaph2	NP_001258530.1	CNDH2_N	7..125	CDD:461866	37/163 (23%)
		CNDH2_M	149..265	CDD:435617	32/169 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..312		23/135 (17%)
		CNDH2_C	308..590	CDD:465283	79/401 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	325..347		8/33 (24%)