Protein Alignment Cap-H2 and NCAPH2

DIOPT Version :10

• Sequence 1: NP_650014.2
• Gene: Cap-H2 / 41289
• FlyBaseID: FBgn0037831
• Length: 960
• Species: Drosophila melanogaster
• Sequence 2: NP_001171940.1
• Gene: NCAPH2 / 29781
• HGNCID: 25071
• Length: 606
• Species: Homo sapiens
• Alignment Length: 853
• Identity: 151/853 - (17%)
• Similarity: 265/853 - (31%)
• Gaps: 284/853 - (33%)

  Fly    41 DEQQDLASLVVLLEELSKNTDYSTDLRISLGYYIEELLRHCLGRNDVSRRSAIVAAGSALQYCGK 105
            |.:...|.|:..:.:|:||  :..|:...||.|:|||.:.|:..::.......:.|...:|....
Human     3 DVEARFAHLLQPIRDLTKN--WEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSAC 65

  Fly   106 IYGDRVEYLCQVVEHQIEALLTSELQKETPSGSAAPEKNERRPEETRKRHPKKLTNKEVDPYLLT 170
            :|..:||||..:|...::.:          ||               ||..|:|::.:.|
Human    66 VYSKKVEYLYSLVYQALDFI----------SG---------------KRRAKQLSSVQED----- 100

  Fly   171 LEPKRFKTMSDDKRFNAAGFVKCTRNRTIEYLYQDHTPPNLWKHAPIVDPHNPYDQDEKKQYKMF 235
                         |.|........:....|:|..|
Human   101 -------------RANGVASSGVPQEAENEFLSLD------------------------------ 122

  Fly   236 TYHVEHRYNTLLPDIPFERLNL-IKEYVHTNQVNTTEILNEHMTTKEYLDEYIALENQMLAARYG 299
                         |.|..|.|: :|.....::|....:|...:...:.:::    .|..|.:|.|
Human   123 -------------DFPDSRTNVDLKNDQTPSEVLIIPLLPMALVAPDEMEK----NNNPLYSRQG 170

  Fly   300 AIVTRRR-----RLVDSAR--FMEDNLDEGLAKKMCMDKNLPMDTNETVLIDQSLVDENSRSLTT 357
            .::..|:     ..|...|  ||.:  .||::         ||:                   ..
Human   171 EVLASRKDFRMNTCVPHPRGAFMLE--PEGMS---------PME-------------------PA 205

  Fly   358 AESTMGISQAENSTLKSSEVEATLSVSHIENSLSDSQEENPPLSSTLAINESSVLDSTRVDPIKD 422
            ..|.|..:|.:....:...:|.::..|.:. :|..|||..|.....:.:...
Human   206 GVSPMPGTQKDTGRTEEQPMEVSVCRSPVP-ALGFSQEPGPSPEGPMPLGGG------------- 256

  Fly   423 LTLDELLLIDSGISMEELSDIQMHTAGQSFDDEGVVLSDLEDQRQLSPMLQMVSPSMEAKTLNII 487
                                          :||     |.|:..:| |.......::|.|.....
Human   257 ------------------------------EDE-----DAEEAVEL-PEASAPKAALEPKESRSP 285

  Fly   488 EMDADLIMNVPREVSYPILLNVMGLPIKRLRRKCIFKLP---PEFDLFRQARLPIKREGQQKSPT 549
            :..|.|    ||..   :|....|.|..   ..|:.:.|   ...|.|........::|:
Human   286 QQSAAL----PRRY---MLREREGAPEP---ASCVKETPDPWQSLDPFDSLESKPFKKGR----- 335

  Fly   550 TPRTVLQIGREAPQNEREPGSPCSLE---------FDEDLNFLGFRQRRPTFDSGFDIEEPRVSS 605
             |.:|.....||...:|:......|:         :.:..:....|::.|:|   .|:|
Human   336 -PYSVPPCVEEALGQKRKRKGAAKLQDFHQWYLAAYADHADSRRLRRKGPSF---ADME------ 390

  Fly   606 CVSTIGEVKTELEDEIEANTNNLTDASASDALNENVNDTKESGLGDSLAQELNASTEPNAENNTA 670
             |.....||.:||        .|......:...:.:...:|..|.||| ::|.|:.:
Human   391 -VLYWTHVKEQLE--------TLRKLQRREVAEQWLRPAEEDHLEDSL-EDLGAAAD-------- 437

  Fly   671 NSSQLEVTATESSGTLSGLETTVDLGMESALVSSVLDLSTEPSAMD-SNIINVTQPDNSDLEIST 734
                            ..||....:..|.|......||...|.::. ..::.    .|.:|.|:|
Human   438 ----------------DFLEPEEYMEPEGADPREAADLDAVPMSLSYEELVR----RNVELFIAT 482

  Fly   735 VQD--QDTLHDEADANDLSAETPNPIADSAVDDCSLIRDWHRRLAPALEAAHERQNFNIKDLGTE 797
            .|.  |:|        :||..               ||||...:.|.|:...:...|:|...|.:
Human   483 SQKFVQET--------ELSQR---------------IRDWEDTVQPLLQEQEQHVPFDIHTYGDQ 524

  Fly   798 ILDICKAGNRTATLADVMADKDPSIMCRYMLASLVLTNHGNVSLDFENRDKSKPIDMSQFRM--H 860
            ::......|.....|:::|.:....:||.|||||.|.|...|.:. :.......:|....|:  |
Human   525 LVSRFPQLNEWCPFAELVAGQPAFEVCRSMLASLQLANDYTVEIT-QQPGLEMAVDTMSLRLLTH 588

  Fly   861 LKSMKRME 868
            .::.||.:
Human   589 QRAHKRFQ 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cap-H2	NP_650014.2	CNDH2_C	<769..862	CDD:465283	25/94 (27%)
NCAPH2	NP_001171940.1	CNDH2_N	6..125	CDD:461866	34/206 (17%)
		CNDH2_M	149..254	CDD:435617	23/139 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..331		33/226 (15%)
		CNDH2_C	316..588	CDD:465283	67/348 (19%)