DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cap-H2 and kle-2

DIOPT Version :9

Sequence 1:	NP_650014.2	Gene:	Cap-H2 / 41289	FlyBaseID:	FBgn0037831	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_498727.2	Gene:	kle-2 / 176116	WormBaseID:	WBGene00016202	Length:	821	Species:	Caenorhabditis elegans

Alignment Length:	967	Identity:	193/967 - (19%)
Similarity:	340/967 - (35%)	Gaps:	278/967 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IAKNRPGTQVAKCIRAYDEQQDLASLVVLLEELSKNTDYSTDLRISLGYYIEELLRHCLGRN--- 85
            :.:|.|..|         |..|||.||...::|.:|  :|.|:..:|..|:|.:.:.....:
Worm     1 MTRNAPPGQ---------ESTDLAWLVTPAKDLVEN--FSIDVLKALAGYLEVIRQESEDTDNQV 54

  Fly    86 ---------DVSRRSAIVAAGSALQYCGKIYGDRVEYLCQVVEHQIEALLTSELQKETPSGSAAP 141
                     |..|...|:....|      :||.:|:::.::....:: |:.::.|.:..:||
Worm    55 DAATTYRLFDFQRACRIIQGSCA------VYGRKVDHVYELTISVVD-LVENKGQDDGNTGS--- 109

  Fly   142 EKNERRPEETRKRHPKKLTN---KEVDPY----LLTLEPKRFKTMSDDKRFNAAGFVKCTRN-RT 198
                ||....||......||   .::|..    |...|    ||:.::|:  :...|:...| ..
Worm   110 ----RRGAGRRKNFNLGSTNYDLADIDSLKQEALANFE----KTVKEEKK--SIDAVRMVENAEV 164

  Fly   199 IEYLYQDHTPPNLWKHAPIVDPHNPYDQDEKKQYKMFTYHVEHRYNTLL-----PDIPFERLNLI 258
            ||..|:.       |...:..|       .:..:|:....:......:|     ||:    :..:
Worm   165 IESQYER-------KSCLVAKP-------TQFMFKLNYGQLNRTDEQILNAKSRPDV----IGKV 211

  Fly   259 KEY-VHTNQV-NTTEILNEHMTTKEYLDEYI------ALENQMLAARYGAIVTRRRRLVDSARFM 315
            |:: :..::| :..:||..|...:..||::.      ..:|:.|||.:|        :.|    :
Worm   212 KDFEIKKSKVKHDQQILYSHDCYRGNLDQFTLPGARWMPDNKELAANFG--------VAD----L 264

  Fly   316 EDNLD-EGLAKKMC-----MDKNLPMDTNETV-----LIDQSLVDEN--------SRSLTTAEST 361
            |..|| |...:|:.     .|   |:...|.|     .|:|..|.:|        ||::|.|..|
Worm   265 EVELDLEQEHEKISAYGPFKD---PLSGREVVPPPRWFIEQEAVRQNQEIQSRATSRAITIAAKT 326

  Fly   362 MGISQ---AENSTLKSSEVEATLSVSHIENSLSDSQ---EENPP-------LSSTLAINESSVLD 413
            :..||   ::.:.|....||.....:|:.:.||..:   .:|.|       |......|..||:.
Worm   327 LRDSQGFGSQPTRLSQPFVERHRQSNHLNDFLSFVEGRVNKNRPSTHLTTGLVDMFVDNFGSVMQ 391

  Fly   414 STRVDPIKDLTLDELLLIDSGISMEELSDIQMHTAGQSFDDEGVVLSDLEDQ---RQLSPMLQMV 475
            :.  :|......||                  :.|...|||:.....|.:|.   |.||...:..
Worm   392 ND--EPNTSRRPDE------------------NYAPMDFDDDFGGGGDDDDDDYIRNLSRRDEKR 436

  Fly   476 SPSM--EAKTLNIIEMDADLIMNVPREVSYPILLNVMGLPIKRLRRKCIFKLPPEFDLFRQARLP 538
            :|:.  |....:||....|  .|:|          |:..|:|::.:   |:..|...|.|:.|
Worm   437 APAPWDELDKNHIIWYTGD--ENLP----------VVSKPVKKITK---FQPKPAEMLARKQR-- 484

  Fly   539 IKREGQQKSPTTPRTVLQIGREAPQNEREPGSPCSLEFDEDLNFL-------GFRQRRPTFDSGF 596
             :.|...||                 .|:       ||.|..::|       ...:..|..|  :
Worm   485 -REEKINKS-----------------RRD-------EFMETHDYLQDYYYWRSAARINPIKD--W 522

  Fly   597 DIEEPRVSSCVSTIGEVKTELEDEIEANTNNLTDASAS--------DALNENVNDTKESGLG--- 650
            .||..|.:........:|.:.....||...|:.....:        :.:.|::..:....||
Worm   523 KIESLRTAILAEKKRRIKEKTAKIREARIQNMQRKRTARVIPVEQFEPVTEDIPTSNRRTLGAEY 587

  Fly   651 -----DSLAQELNAS------------TEPNAENNTANSSQLEVTATESSGTLSGLETTVDL--- 695
                 :.||.|:..|            ..|..|......:.||..|         |:|..|:
Worm   588 DDVVDEDLAAEVELSMFGGGFDDDEEDVRPRGERPPMAPNNLEFDA---------LQTDFDIPPA 643

  Fly   696 --------GMESALVSSVLDLSTEPSAMDSNIINVTQPDNSDLEISTVQDQDTLHDEADANDLSA 752
                    .::.|.::||::|                |.|..::.:....:....:..|...::.
Worm   644 EYVPLRFEDIDDAELNSVINL----------------PGNLLIDKALPLLKKFAENRTDREQMAY 692

  Fly   753 ETPNPIADSAVDDCSL---IRDWHRRLAPALEAAHERQNFNIKDLGTEILDICKAGNRTATLADV 814
            |......|..|...:|   :..||.|:.|.||....|:.:::..:|..::........|..|.|:
Worm   693 EMAKAYEDVDVAVSTLQEHVDKWHSRMEPILEEGETRKEYDVHAVGRAVIGQYDIEGGTKRLLDL 757

  Fly   815 MADKDPSIMCRYMLASLVLTNHGNV------SLDFENRDKSKPIDMSQFRMHLKSMK 865
            :.|:....:.||.|:.|.:.|.|||      .|..|.|..|..|.:.:..||.:..|
Worm   758 VMDRPWYEISRYFLSCLFMCNVGNVMVSEDMELPLEERINSMKITLLKRDMHCEMFK 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cap-H2	NP_650014.2	CNDH2_C	<769..844	CDD:293463	21/80 (26%)
kle-2	NP_498727.2	CNDH2_N	17..>110	CDD:283849	20/108 (19%)
kle-2	NP_498727.2	CNDH2_C	<706..806	CDD:293463	26/99 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2359
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005551
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14324
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2597
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030