DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MED7 and MED7

DIOPT Version :9

Sequence 1:	NP_731500.1	Gene:	MED7 / 41288	FlyBaseID:	FBgn0051390	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_001094286.1	Gene:	MED7 / 9443	HGNCID:	2378	Length:	233	Species:	Homo sapiens

Alignment Length:	228	Identity:	119/228 - (52%)
Similarity:	157/228 - (68%)	Gaps:	23/228 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QVSSLPMPPERYIANYTDENIRRNRAPRPPPPPAQHEVYSMFGIQYNNDEM-IRSLESQNIKRLI 70
            |||:||.||.:||..||||||:...||:||||  ..:.|.|||.|:..|:: ||.||||.|:||.
Human     6 QVSALPPPPMQYIKEYTDENIQEGLAPKPPPP--IKDSYMMFGNQFQCDDLIIRPLESQGIERLH 68

  Fly    71 PIHFDRRKELKKLNHSLLVNFLDLIDFLILNPDSPRRTEKIDDISLLFVNMHHLLNEFRPHQARE 135
            |:.||.:|||:|||.|:|:|||||:|.||.:|.|.:|.||::|:.||||::|||:||:|||||||
Human    69 PMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARE 133

  Fly   136 TLRVMMEMQKRQRVETAARFQKHLERVREIVNTAFSALPVLDD-DDDSGGAKIKTEVDPLEA--- 196
            |||||||:|||||:|||.|||||||||.|::....::||  || .....|.::|||  |::|
Human   134 TLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLP--DDLPHSEAGMRVKTE--PMDADDS 194

  Fly   197 ------------NAAAKNDPSYQHDRMLCKLVD 217
                        |:..:.|...:.|..||.|:|
Human   195 NNCTGQNEHQRENSGHRRDQIIEKDAALCVLID 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED7	NP_731500.1	Med7	8..166	CDD:283604	101/158 (64%)
MED7	NP_001094286.1	Med7	7..164	CDD:399168	100/157 (64%)
MED7	NP_001094286.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..213		9/40 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	201	1.000	Domainoid score	I3026
eggNOG	1	0.900	-	-		E1_KOG0570
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3153
Inparanoid	1	1.050	221	1.000	Inparanoid score	I3560
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57344
OrthoDB	1	1.010	-	-		D1356482at2759
OrthoFinder	1	1.000	-	-		FOG0004483
OrthoInspector	1	1.000	-	-		oto89337
orthoMCL	1	0.900	-	-		OOG6_103150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R706
SonicParanoid	1	1.000	-	-		X3177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770