Protein Alignment CG14691 and SV2A

DIOPT Version :9

• Sequence 1: NP_650012.2
• Gene: CG14691 / 41287
• FlyBaseID: FBgn0037829
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_001315603.1
• Gene: SV2A / 9900
• HGNCID: 20566
• Length: 742
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 134/610 - (21%)
• Similarity: 241/610 - (39%)
• Gaps: 107/610 - (17%)

  Fly     2 ADRAKDNTDEPADFETAIAECGFGLFN---VFILCSAVPCLTAMVFSASALSYVMPSAECDLDLS 63
            |.|.|:..:....:|..:.|||.|.|.   .|:|..|:......||   .:.:|:||||.|:.||
Human   139 AQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADGVEVF---VVGFVLPSAEKDMCLS 200

  Fly    64 IVDKGMLHAVTYAGMIISAVPWGFIADTIGRRPVLISGGWLDGFFVLCASLSQNTAQLMAFKFFD 128
            ..:||||..:.|.||::.|..||.:||.:|||..|:....::..|...:|..|.....:..:...
Human   201 DSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLS 265

  Fly   129 GLIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLP-VPILFTV-SSMKF 191
            |:.|.|...:|.||.:||..::.|...:.::.:...||.:....:::.::| ....|.: |:.:|
Human   266 GVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQF 330

  Fly   192 RTWQVFLAVSSAPSLLSGFLHIFLPESPKFLMSQGNYKKALDSLQRIYKLNKRKS---RESYPIK 253
            .:|:||:.|.:.||:.:.......||||:|.:..|.:.:|...|::::..|.|..   ...:.:.
Human   331 HSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVT 395

  Fly   254 HLTDPTPDRSDDL----DGTGRPSTLQERFS-RAQSKFIDGFKQLKPMFSSPYLAISLQVYCLHF 313
            |:  .|..:.|:|    ..||   |..:|:. ||.|.....:......|...|..|:|.:..:.|
Human   396 HI--KTIHQEDELIEIQSDTG---TWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWF 455

  Fly   314 CQIMCVNSVRLWLPQIFATMNAMDTLGANDTSMCAVLEH-----------------------NAN 355
            ........:.:|.|.:...:.|:|............:||                       ...
Human   456 TMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLR 520

  Fly   356 AKSMDEEEKRVECALHHDPDS----------------------------------YLNN-----I 381
            .||:..|:...|.....|..|                                  :|:|     :
Human   521 LKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPL 585

  Fly   382 TVAGIGLVGFLIIFP--LMRFQVVSNHILKVFLFICIFLVGSLYFVKTSLVTMMVSAVYLTMMG- 443
            .|.|.|...:::.|.  |....|:..:|:...|   :..:|.|..:..|.|...||..:|:...
Human   586 DVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALL---MDKIGRLRMLAGSSVMSCVSCFFLSFGNS 647

  Fly   444 ----ICATTIIG------------MSVVIFPTLMRTMVLLLIMTFGRLGSVSGNMLLPVFMQLSC 492
                |....:.|            ::|.::|:..||.....:....:|.:|.|..:...|:.::.
Human   648 ESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITK 712

  Fly   493 LAPFLWLCSLMSIAFLFSLFLKVDD 517
            .||.|:..:.:::.  .||.||:.:
Human   713 AAPILFASAALALG--SSLALKLPE 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	53/187 (28%)
SV2A	NP_001315603.1	synapt_SV2	1..742	CDD:130366	134/610 (22%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..144		2/4 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5294
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870