DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14691 and SLC22A8

DIOPT Version :9

Sequence 1:	NP_650012.2	Gene:	CG14691 / 41287	FlyBaseID:	FBgn0037829	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001171661.1	Gene:	SLC22A8 / 9376	HGNCID:	10972	Length:	542	Species:	Homo sapiens

Alignment Length:	492	Identity:	113/492 - (22%)
Similarity:	182/492 - (36%)	Gaps:	143/492 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PCLTAMVFSASALSYVMPSAECDLDL-SIVDKGMLHAVTYAGMIISAVPWGFIADTIGRRPVLIS 100
            |||...|::::..|.|   .|.||.. |...|.|..::..||::|..:..|.::|..||||:|..
Human    94 PCLDGWVYNSTKDSIV---TEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTC 155

  Fly   101 GGWLDGFFVLCAS-----LSQNTAQLMAFKFFDGLIICGPFAVVVSYLAEFHGKKHRPYIMLFVG 160
                 .:.:|.||     .|......|.|:|..|..|.|.....|....|:...:.|..:...:|
Human   156 -----SYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALG 215

  Fly   161 LCVSIGSMILPLLSYLLLPVPILFTVSSMKFRTWQVFLAVSSAPSLLSGFLHIFLPESPKFLMSQ 225
            .|.:.|..|||.|:|   .:|        ::|..|:.:::......||.:   :.|||.::|:..
Human   216 YCYTFGQFILPGLAY---AIP--------QWRWLQLTVSIPFFVFFLSSW---WTPESIRWLVLS 266

  Fly   226 GNYKKALDSLQRIYKLN-KRKSRESYPIKHLTDPTPDRSDDLDGTGRPSTLQERFSRAQSKFI-- 287
            |...|||..|:|:...| |::..|...::.|                ...||:..|.|::|:.
Human   267 GKSSKALKILRRVAVFNGKKEEGERLSLEEL----------------KLNLQKEISLAKAKYTAS 315

  Fly   288 DGFKQLKPMFSSPYLAISLQVYCLHFCQ---IMCVN--SVRLWLPQI----------FATMNAMD 337
            |.|:  .||.......:||..:...|..   .|.|.  .|.|::.||          |.|:.::.
Human   316 DLFR--IPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLS 378

  Fly   338 TLGANDTSMCAVLEHNANAKSMDEEEKRVECALHHDPDSYLNNITVAGIGLVGFLIIFPLMRFQV 402
            .||.:.|...|:|                                :|| |.:..|...|| ..|.
Human   379 YLGRHTTQAAALL--------------------------------LAG-GAILALTFVPL-DLQT 409

  Fly   403 VSNHILKVF-------LFICIFLVGSLYFVKTSLVTMMVSAVYLTMMGICATTIIGMSVVIFPTL 460
            |.. :|.||       .|.|:||..|                                 .::||:
Human   410 VRT-VLAVFGKGCLSSSFSCLFLYTS---------------------------------ELYPTV 440

  Fly   461 MRTMVLLLIMTFGRLGSVSGNMLLPVFMQLSCLAPFL 497
            :|...:.:...:.|:||    |:.|:......:.||:
Human   441 IRQTGMGVSNLWTRVGS----MVSPLVKITGEVQPFI 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	48/184 (26%)
SLC22A8	NP_001171661.1	2A0119	11..503	CDD:273328	113/492 (23%)
		MFS	96..493	CDD:119392	111/490 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153591
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850