DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14691 and SLC22A16

DIOPT Version :9

Sequence 1:	NP_650012.2	Gene:	CG14691 / 41287	FlyBaseID:	FBgn0037829	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_149116.2	Gene:	SLC22A16 / 85413	HGNCID:	20302	Length:	577	Species:	Homo sapiens

Alignment Length:	472	Identity:	98/472 - (20%)
Similarity:	182/472 - (38%)	Gaps:	160/472 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 GMIISAVPWGFIADTIGRRPVLISGGWLDG----FFVLCASLSQNTAQLMAFKFFDGLIICGPFA 137
            |:::.:|.:|:.:|.:|||.||    |...    .|.:.|:.:.:....||.:||..::..|...
Human   164 GVLLGSVTFGYFSDRLGRRVVL----WATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLV 224

  Fly   138 VVVSYLAEFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLPVPILFTVSSMKFRTW---QVFLA 199
            |...|:.||.|.|.|.:..:.:....::|::::.|..||:              |||   |:.|:
Human   225 VGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLV--------------RTWWLYQMILS 275

  Fly   200 VSSAPSLLSGFLHIFLPESPKFLMSQGNYKKALDSLQRIYKLNKRKSRESYPIKHLTDPTPDRSD 264
            ..:.|.:|..::   |||:|.:|:|:|.|::|...:..:.|.|:..|.:...:..|
Human   276 TVTVPFILCCWV---LPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSL--------- 328

  Fly   265 DLDGTGRPSTLQERFSRAQSKFIDGFKQLKPMFSSPYLAISLQVYCLHFCQIMCVNSVRLWLPQI 329
            ||.|                          |:.:||.......:..|.:...:...::.:||  |
Human   329 DLQG--------------------------PVSNSPTEVQKHNLSYLFYNWSITKRTLTVWL--I 365

  Fly   330 FATMNAMDTLGANDTSMCAVLEHNANAKSMDEEEKRVECALHHDPDSYLNNITVAGIGLVGFLII 394
            :.|    .:||....|:        |:.::...|             |||      :.|:|.:.|
Human   366 WFT----GSLGFYSFSL--------NSVNLGGNE-------------YLN------LFLLGVVEI 399

  Fly   395 FPLMRFQVVSNHILKVFLFICIFL--VG-------SLYFVKTSLVTMMVSAVYLTMMGICATTII 450
                          ..:.|:||.:  ||       ||:....:...:||......::|: .|.::
Human   400 --------------PAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGV-VTAMV 449

  Fly   451 GMSVV-------------IFPTLMRTMVLLLIMTFGRLGSVSGNMLLPVFMQLSCLAPF------ 496
            |...:             ::||::|::.:           .||:|   |....|.||||
Human   450 GKFAIGAAFGLIYLYTAELYPTIVRSLAV-----------GSGSM---VCRLASILAPFSVDLSS 500

  Fly   497 LWLCSLMSIAFLFSLFL 513
            :|:       |:..||:
Human   501 IWI-------FIPQLFV 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	35/145 (24%)
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	98/472 (21%)
SLC22A16	NP_149116.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..577
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153538
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850