DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14691 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_650012.2	Gene:	CG14691 / 41287	FlyBaseID:	FBgn0037829	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_112622.1	Gene:	Slc22a8 / 83500	RGDID:	632286	Length:	536	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	108/485 - (22%)
Similarity:	185/485 - (38%)	Gaps:	129/485 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PCLTAMVFSASALSYVMPSAECDLDLSIVD-KGMLHAVTYAGMIISAVPWGFIADTIGRRPVLIS 100
            |||...:::::..:.|:   |.||..|... |.|..::..||:::.....|.::|..||:|:|.
  Rat    94 PCLDGWIYNSTRDTIVI---EWDLVCSSNKLKEMAQSIFMAGILVGGPVIGELSDRFGRKPILT- 154

  Fly   101 GGWLDGFFVLCAS-----LSQNTAQLMAFKFFDGLIICGPFAVVVSYLAEFHGKKHRPYIMLFVG 160
              |  .:.:|.||     .|.:....|.|:|..|..|.|.....|....|:.....|......:|
  Rat   155 --W--SYLMLAASGSGAAFSPSLPVYMIFRFLCGCSISGISLSTVILNVEWVPTSMRAISSTSIG 215

  Fly   161 LCVSIGSMILPLLSYLLLPVPILFTVSSMKFRTWQVFLAVSSAPSLLSGFLHIFLPESPKFLMSQ 225
            .|.:||..||..|:|   .:|           .|:.....||||..:...|..::|||.::|:..
  Rat   216 YCYTIGQFILSGLAY---AIP-----------QWRWLQLTSSAPFFIFSLLSWWVPESIRWLVLS 266

  Fly   226 GNYKKALDSLQRIYKLN-KRKSRESYPIKHLTDPTPDRSDDLDGTGRPSTLQERFSRAQSKFIDG 289
            |.|.|||.:|||:...| |::..:...|:.|                ...||:..:.|:.|:
  Rat   267 GKYSKALKTLQRVATFNGKKEEGKKLTIEEL----------------KFNLQKDITSAKVKY--- 312

  Fly   290 FKQLKPMFSSPYLAISLQV-YCLHFCQIMCVNSVRLWLPQIFATMNAMDTLGANDTSMCAVLEHN 353
              .|..:|.   ::|..:| :||...          |    |:|..|..:|
  Rat   313 --GLSDLFR---VSILRRVTFCLSLA----------W----FSTGFAYYSL-------------- 344

  Fly   354 ANAKSMDEEEKRVECALHHDPDSYLNNITVAGIGL-VGFLIIFPLMRFQVVSNHILKVFLFI--- 414
                :|..||..|        :.|:..|...|:.: ..|:.|..|   ..:...|.:.||.:
  Rat   345 ----AMGVEEFGV--------NIYILQIIFGGVDIPAKFITILSL---SYLGRRITQSFLLLLAG 394

  Fly   415 -----CIFLVGSLYFVKTSLVTM-------MVSAVYLTMMGICATTIIGMSVVIFPTLMRTMVLL 467
                 .||:...:..::|:|...       ..|.::|            .:..::||::|...:.
  Rat   395 GAILALIFVPSEMQLLRTALAVFGKGCLSGSFSCLFL------------YTSELYPTVLRQTGMG 447

  Fly   468 LIMTFGRLGSVSGNMLLPVFMQLSCLAPFL 497
            :...:.|:||    |:.|:......|.||:
  Rat   448 ISNVWARVGS----MIAPLVKITGELQPFI 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	47/184 (26%)
Slc22a8	NP_112622.1	2A0119	11..503	CDD:273328	108/485 (22%)
		MFS	124..492	CDD:119392	99/452 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347179
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850