Protein Alignment CG14691 and Sv2c

DIOPT Version :9

• Sequence 1: NP_650012.2
• Gene: CG14691 / 41287
• FlyBaseID: FBgn0037829
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_083486.1
• Gene: Sv2c / 75209
• MGIID: 1922459
• Length: 727
• Species: Mus musculus
• Alignment Length: 616
• Identity: 132/616 - (21%)
• Similarity: 235/616 - (38%)
• Gaps: 126/616 - (20%)

  Fly     2 ADRAKDNTDEPADFETAIAECGFGLFN---VFILCSAVPCLTAMVFSASALSYVMPSAECDLDLS 63
            ::|..|..:....:|..|.|||.|.|.   .|:|..|:......||   .:.:|:||||.||.:.
Mouse   125 SERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVF---VVGFVLPSAETDLCIP 186

  Fly    64 IVDKGMLHAVTYAGMIISAVPWGFIADTIGRRPVLISGGWLDGFFVLCASLSQNTAQLMAFKFFD 128
            ....|.|.::.|.||::.|..||.:||.:||:..|:....::|||...:|..|.....:..:...
Mouse   187 NSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLVCRLLS 251

  Fly   129 GLIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLP-VPILFTV-SSMKF 191
            |..|.|....|.||.||...::.|...:.::.:...||.:....:::.::| ....|:: |:.:|
Mouse   252 GFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQF 316

  Fly   192 RTWQVFLAVSSAPSLLSGFLHIFLPESPKFLMSQGNYKKALDSLQRIYKLNKRKSRESYPIKHLT 256
            .:|:||:.|.:.|.:.|.....|:||||:||:..|.:.:|...|:.|:..|.|  ....|.|..|
Mouse   317 HSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMR--ARGQPEKVFT 379

  Fly   257 ---DPTPDRSDDL----DGTGRPSTLQER-FSRAQSKFIDGFKQLKPMFSSPYLAISLQVYCLHF 313
               ..||.:.|:|    ..||   |...| |.|.:::....:......|:.|....::::..:.|
Mouse   380 VNKIKTPKQIDELIEIESDTG---TWYRRCFVRIRTELYGIWLTFMRCFNYPVRENTIKLTIVWF 441

  Fly   314 CQIMCVNSVRLWLPQI---------------------------FATMNAMDT---------LGAN 342
            ........:.:|.|.:                           |...|.:.|         ||..
Mouse   442 TLSFGYYGLSVWFPDVIKHLQSDEYALLTRNVQKDKYANFSINFTMENQIHTGMEYENGRFLGVK 506

  Fly   343 DTSM------------------------CAVLE---HNAN---AKSMDEE-------EKRVECAL 370
            ..|:                        |..::   .|.:   .|.:|.|       ..:..|.:
Mouse   507 FKSVTFKDSVFKSCTFDDVTSVNTYFKNCTFIDTLFDNTDFEPYKFIDSEFQNCSFLHNKTGCQI 571

  Fly   371 HHDPDSYLNNITVAGIGLVGFLIIFPLMRFQVVSNHILKVFLFICIFLVGSLYFVKTSLVTMMVS 435
            ..|.|  .:...:..:..:|.|.:.|        .:|:...|   :..:|.|..:..|:|...:|
Mouse   572 TFDDD--YSAYWIYFVNFLGTLAVLP--------GNIVSALL---MDRIGRLTMLGGSMVLSGIS 623

  Fly   436 AVYLTMMGICATTIIGM------------------SVVIFPTLMRTMVLLLIMTFGRLGSVSGNM 482
            ..:| ..|...:.:|||                  :|.::||..|......:....:..:|.||:
Mouse   624 CFFL-WFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNL 687

  Fly   483 LLPVFMQLSCLAPFLWLCSLMSIAFLFSLFL 513
            :....:.::...|.|...:::....|..|.|
Mouse   688 IFGSLVSITKAIPILLASTVLVCGGLVGLRL 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	52/187 (28%)
Sv2c	NP_083486.1	synapt_SV2	1..727	CDD:130366	132/616 (21%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..128		0/2 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920