Protein Alignment CG14691 and SLC22A3

DIOPT Version :9

• Sequence 1: NP_650012.2
• Gene: CG14691 / 41287
• FlyBaseID: FBgn0037829
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 488
• Identity: 104/488 - (21%)
• Similarity: 181/488 - (37%)
• Gaps: 132/488 - (27%)

  Fly    36 VPCLTAMVFSASALSYVMPSAECDLDLSIVDKGML---HAVTYAGMIISAVPWGFIADTIGRRPV 97
            |||.....: |.|.|.::    .:.||..|:..||   .|:...|.:..|...|:.||..||..:
Human   125 VPCRGGWRY-AQAHSTIV----SEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVI 184

  Fly    98 -LIS--GGWLDGFFVLCASLSQNTAQLMAFKFFDGLIICGPFAVVVSYLAEFHGKKHRPYIMLFV 159
             |:|  |..:.|..|   :.:.|....:.|:|..|:...|.:......:.|..|.|.|..:.:.:
Human   185 YLLSCLGVGVTGVVV---AFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVI 246

  Fly   160 GLCVSIGSMILPLLSYLLLPVPILFTVSSMKFRTWQVFLAVSSAPSLLSGFLHIFLPESPKFLMS 224
            .:..::|.:|||.::|.   :|           .||......:.||.|....:..:||||::|::
Human   247 QMFFTLGIIILPGIAYF---IP-----------NWQGIQLAITLPSFLFLLYYWVVPESPRWLIT 297

  Fly   225 QGNYKKALDSLQRIYKLNKRKSRESYPIKHLTDPTPDRSDDLDGTGRPSTLQERFSRAQSKFIDG 289
            :....|||..|:||.|.|.:....:|....:||         :....||            |:|
Human   298 RKKGDKALQILRRIAKCNGKYLSSNYSEITVTD---------EEVSNPS------------FLD- 340

  Fly   290 FKQLKPMFSSPYLAISLQVYCLHFCQIMCVNSVRLWLPQIFATMNAMDTLGANDTSMCAVLEHNA 354
                  :..:|.         :..|.::.:.:   |..........:..||        ::..|.
Human   341 ------LVRTPQ---------MRKCTLILMFA---WFTSAVVYQGLVMRLG--------IIGGNL 379

  Fly   355 NAKSMDEEEKRVECALHHDPDSYLNNITVAGIGLVGFLIIFPLMRFQ--------VVSNHILKVF 411
                                  |::......:.|.|.|:|  |:..:        ..||.:..|.
Human   380 ----------------------YIDFFISGVVELPGALLI--LLTIERLGRRLPFAASNIVAGVA 420

  Fly   412 LFICIFLVGSLYFVKTSL-------VTMMVSAVYLTMMGICATTI--IGMSV---------VIFP 458
            ..:..||...:.:::|::       :||....|||....:..||:  .|:|:         :|.|
Human   421 CLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAP 485

  Fly   459 TLMRTMVL----LLIMTFGRLGSVSGN--MLLP 485
            .|:..:..    |.::.||.|.|:.|.  ||||
Human   486 FLLFRLAAVWLELPLIIFGILASICGGLVMLLP 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	44/185 (24%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	104/488 (21%)
		MFS	149..518	CDD:119392	94/457 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153600
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850