Protein Alignment CG14691 and Sv2b

DIOPT Version :9

• Sequence 1: NP_650012.2
• Gene: CG14691 / 41287
• FlyBaseID: FBgn0037829
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_001103223.1
• Gene: Sv2b / 64176
• MGIID: 1927338
• Length: 683
• Species: Mus musculus
• Alignment Length: 613
• Identity: 131/613 - (21%)
• Similarity: 253/613 - (41%)
• Gaps: 103/613 - (16%)

  Fly     1 MADRAKDNTDEPADFETAIAECGFGLFN---VFILCSAVPCLTAMVFSASALSYVMPSAECDLDL 62
            ||:|.:|..:....:||.|.|||.|.|.   .|:|..|:......:|   .:|:.:||||.|:.|
Mouse    81 MAERMEDEEELAHQYETIIDECGHGRFQWTLFFVLGLALMADGVEIF---VVSFALPSAEKDMCL 142

  Fly    63 SIVDKGMLHAVTYAGMIISAVPWGFIADTIGRRPVLISGGWLDGFFVLCASLSQNTAQLMAFKFF 127
            |...||||..:.|.||:..|...|.:||.:||:.||.....::..|...:|..|.....:..:..
Mouse   143 SSSKKGMLGLIVYLGMMAGAFILGGLADKLGRKKVLSMSLAINASFASLSSFVQGYGAFLFCRLI 207

  Fly   128 DGLIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLP-VPILFTV-SSMK 190
            .|:.|.|...:|.:|.:||..::.|...:.::|:....|.:....:::.::| ....|:: ::..
Mouse   208 SGIGIGGSLPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGIYASAMAWSIIPHYGWGFSMGTNYH 272

  Fly   191 FRTWQVFLAVSSAPSLLSGFLHIFLPESPKFLMSQGNYKKALDSLQRIYKLNKRKS---RESYPI 252
            |.:|:||:.|.:.|:.:|.....|:||||:||:..|.:.:|...|::::..|.|..   .:.:.:
Mouse   273 FHSWRVFVIVCALPATVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTV 337

  Fly   253 KHLTDPTPDRSDDL----DGTGRPSTLQERFSRAQSKFIDGFKQL--KPMF--SSPYLAISLQVY 309
            .|:  .||.:.|:.    ..||      ..:.|...:|:..|||:  ..::  ..||...:|.:.
Mouse   338 SHI--KTPKQMDEFIEIQSSTG------TWYQRWLVRFMTIFKQVWDNALYCVMGPYRMNTLILA 394

  Fly   310 CLHFCQIMCVNSVRLWLPQIF---------ATMNAMDTLGANDTSMCAVLEHNANAKSMDEEEKR 365
            .:.|...:....:.:|.|.:.         :.|........:..::...:|:..:.......:|.
Mouse   395 VVWFTMALSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVHGATINFTMENQIHQHGKLVNDKF 459

  Fly   366 VECALHH-----------------DPDSYLNNITVAGIGLVGF-LIIFPLMRFQVVSNHILKV-- 410
            ::....|                 ..|:|..|.|:........ |.....:..:.:::..|:.
Mouse   460 IKMYFKHVLFEDTFFDKCYFEDVTSTDTYFKNCTIESTTFYNTDLYKHKFINCRFINSTFLEQKE 524

  Fly   411 -----------FLFICIFLVGSLYFVKTSLV----------------TMMVSAV---YL------ 439
                       ||...:..:|||..:..:::                :|::|||   :|
Mouse   525 GCHMDFEEDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSE 589

  Fly   440 -TMMG----ICATTIIG------MSVVIFPTLMRTMVLLLIMTFGRLGSVSGNMLLPVFMQLSCL 493
             .|:|    .|.|:|..      ::|.::||..|.....::....:.|::.||.:...|:.::.:
Mouse   590 SAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKV 654

  Fly   494 APFLWLCSLMSIAFLFSLFLKVDDEQSL 521
            .|.|...:.:....|.:|.|....||.|
Mouse   655 VPILLAAASLVGGGLIALRLPETREQVL 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	50/187 (27%)
Sv2b	NP_001103223.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..73
		synapt_SV2	8..683	CDD:130366	131/613 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920