Protein Alignment CG14691 and SLC22A23

DIOPT Version :10

• Sequence 1: NP_650012.2
• Gene: CG14691 / 41287
• FlyBaseID: FBgn0037829
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: XP_054212174.1
• Gene: SLC22A23 / 63027
• HGNCID: 21106
• Length: 718
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 107/503 - (21%)
• Similarity: 177/503 - (35%)
• Gaps: 122/503 - (24%)

  Fly    57 ECDLDLSIVDKGMLHAVTYA---GMIISAVPWGFIADTIGRRPVLISGGWLDGFFVLCASLSQNT 118
            |.:.||...:...:|...::   |:|...:..|.|||.:||||||:........|.|..:||.|.
Human   240 ELNWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNV 304

  Fly   119 AQLMAFKFFDGLIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLPVPIL 183
            ......:||:|..:.|....:.:...|......|..|.:........|..::|.|:.|.
Human   305 TMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALC------ 363

  Fly   184 FTVSSMKFRTWQVFLAVSSAPSLLSGFLHIFLPESPKFLMSQGNYKKALDSLQRIYKLNKRKSRE 248
                    |.|||..|:...|.||........|||.::||:...::.|           ||.
Human   364 --------RDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESA-----------KRL--- 406

  Fly   249 SYPIKHLTDPTPDRSDDLDGTGRPSTLQERFSRAQSKFIDGFKQLKPMFSSPYLAISLQVYCLHF 313
               |.|.|... ..:.:.|..|....|::..||...|                           .
Human   407 ---ILHFTQKN-RMNPEGDIKGVIPELEKELSRRPKK---------------------------V 440

  Fly   314 CQIMCVNSVRLWLPQIFATMNAMDTLGANDTSMCAVLEHNANAKSMDEEEKRVECALHHDPDSYL 378
            |.:..|.:..||...:...:|::...|.          |:..|:||...|.:|....:...|.|
Human   441 CIVKVVGTRNLWKNIVVLCVNSLTGYGI----------HHCFARSMMGHEVKVPLLENFYADYY- 494

  Fly   379 NNITVAGIGLVGFLIIFPLMRFQVVSNHILKVFLFICIFLVGSLYFVKTSLVTMMVS-------- 435
               |.|.|.||..|.:..::||......:|   ||:.:..:.||  ::..|:.::..
Human   495 ---TTASIALVSCLAMCVVVRFLGRRGGLL---LFMILTALASL--LQLGLLNLIGKYSQHPDSE 551

  Fly   436 -----------------AVYLTMMGICATTIIGMSVVIF-----PTLMRTMVLLLIMTFGRLGSV 478
                             ::..:::|:.|:..:|...|.|     ||::|...|.|:     |.|.
Human   552 LQLKLAVGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLV-----LASA 611

  Fly   479 SGNMLLPVFMQLS-----CLAPFLWLCSLMSIAFLFSLFLKVDDEQSL 521
            ...||....::|.     .|...::.|..: |..:..|.|....:|:|
Human   612 GFGMLTAPIIELHNQKGYFLHHIIFACCTL-ICIICILLLPESRDQNL 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	synapt_SV2	2..>337	CDD:130366	62/282 (22%)
		MFS	<375..513	CDD:475125	35/172 (20%)
SLC22A23	XP_054212174.1	MFS_SLC22A23	192..637	CDD:341002	101/479 (21%)