DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14691 and sv2

DIOPT Version :9

Sequence 1:	NP_650012.2	Gene:	CG14691 / 41287	FlyBaseID:	FBgn0037829	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_009296040.1	Gene:	sv2 / 570651	ZFINID:	ZDB-GENE-000607-80	Length:	522	Species:	Danio rerio

Alignment Length:	536	Identity:	156/536 - (29%)
Similarity:	253/536 - (47%)	Gaps:	70/536 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DNTDEPAD------FETAIAECGFGLFNVFILCSAVPCLTAMVFSA---SALSYVMPSAECDLDL 62
            :..||.|.      :|.|:.:.|||||:..:|   |.|..|....|   ..:|:::|:|.|||.|
Zfish    19 EEDDEQASCRKKLTYEEAVEKAGFGLFHWLLL---VVCGWANASDAVEILCVSFLLPTARCDLQL 80

  Fly    63 SIVDKGMLHAVTYAGMIISAVPWGFIADTIGRRPVLISGGWLDGFFVLCASLSQNTAQLMAFKFF 127
            |..|.|:|.|..:.||::....|||:||..|||.||:....::|.|...|||:......:..:||
Zfish    81 SSADMGILTASIFLGMMVGGCVWGFLADRRGRRSVLVVSLAVNGTFGAVASLAPTFWLFLLLRFF 145

  Fly   128 DGLIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLCVSIGSMILPL-------------LSYLLLP 179
            .|:.:.|...|:.||.:||     :|        |:..|:||..|             :::|::|
Zfish   146 SGVGVGGSIPVIFSYFSEF-----QP--------CLRRGAMISALATFWMAGNILAAGVAWLVIP 197

  Fly   180 VPILFT-VSSMKFRTWQVFLAVSSAPSLLSGFL-HIFLPESPKFLMSQGNYKKALDSLQRIYKLN 242
            ...|.. ...:.|::|::|:.:.|.|||.|..: .:|:||||||||..|...:||...|:|||||
Zfish   198 RTSLHADWGWLDFQSWRLFVVLCSIPSLSSALIFRLFMPESPKFLMEAGREMEALSVFQKIYKLN 262

  Fly   243 KRKSRESYPIKHLTDPTPDRSDDLDGTGRPSTLQERFSRAQSKFIDGFKQLKPMFSSPYLAISLQ 307
            .|.:.:.:|:..|.    .|..|.:...|||....|..|..::.......||.:|..|..:.|:.
Zfish   263 NRGATKPFPVSGLM----IRPKDDEVKNRPSHSSSRSQRFINQLTQALVPLKQLFVRPLASRSVV 323

  Fly   308 VYCLHFCQIMCVNSVRLWLPQIFATMNAMDTLGAND-TSMCAVLEHNANAKSMDEEEK--RVECA 369
            :..:.||.......:.:|.|::|..        |.| .|.||.:....||    |.||  .|:.|
Zfish   324 LVIIFFCISFGYYGLWMWFPELFKR--------AEDGGSPCANMSRAQNA----ENEKCYPVKTA 376

  Fly   370 LHHDPDSYLNNITVAGIGLVGFLIIFPLMRFQVVSNHILKVFLFICIFLVGSLYFVKTSLVTMMV 434
            :      |:.....|...|.|.:....||. ::....:|.|.|.:....|..:|.|||...:::|
Zfish   377 V------YMEGFITAASNLPGNIFTILLMD-RIGGKILLSVSLLVSGVSVFVIYVVKTKTQSLIV 434

  Fly   435 SAVY--LTMMGICATTIIGMSVVIFPTLMRTMVLLLIMTFGRLGSVSGNMLLPVFMQLSCLAPFL 497
            |.|:  ::::...|..::|..  ::||.:|:..|.:....||:.::.||::....:..||..|.|
Zfish   435 SCVFSGVSVISWNALDVVGTE--LYPTQLRSSALGVFTGVGRVAAIMGNVVFGQLVDSSCAVPLL 497

  Fly   498 WLCSLMSIAFLFSLFL 513
            .:|.|:....|.:|:|
Zfish   498 MVCVLLLAGGLAALWL 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	61/203 (30%)
sv2	XP_009296040.1	2A0115	33..488	CDD:273327	144/495 (29%)
sv2	XP_009296040.1	MFS	50..500	CDD:119392	141/490 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920