DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14691 and sv2a

DIOPT Version :9

Sequence 1:	NP_650012.2	Gene:	CG14691 / 41287	FlyBaseID:	FBgn0037829	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_696434.2	Gene:	sv2a / 568033	ZFINID:	ZDB-GENE-131001-1	Length:	733	Species:	Danio rerio

Alignment Length:	607	Identity:	127/607 - (20%)
Similarity:	240/607 - (39%)	Gaps:	110/607 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DRAKDNTDEPADFETAIAECGFGLFN---VFILCSAVPCLTAMVFSASALSYVMPSAECDLDLSI 64
            :|.||..:....:||.:.|||.|.|.   .|:|..|:......:|   .:.:|:||||.|:.||.
Zfish   132 ERRKDQEELAQQYETILQECGHGRFQWTLYFVLGLALMADGVEIF---VVGFVLPSAEKDMCLSE 193

  Fly    65 VDKGMLHAVTYAGMIISAVPWGFIADTIGRRPVLISGGWLDGFFVLCASLSQNTAQLMAFKFFDG 129
            .:||||..:.|.||::.|..||.:||.||||..|:....::..|...:|..|..:..:..:...|
Zfish   194 PNKGMLGLIVYLGMMVGAFVWGGLADRIGRRQTLLISLSINSVFAFFSSFVQGYSSFLFCRLLSG 258

  Fly   130 LIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLP-VPILFTV-SSMKFR 192
            :.|.|...:|.||.:||..::.|...:.::.:...||.:....:::.::| ....|.: |:.:|.
Zfish   259 VGIGGSIPIVFSYYSEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGWSFQMGSAYQFH 323

  Fly   193 TWQVFLAVSSAPSLLSGFLHIFLPESPKFLMSQGNYKKALDSLQRIYKLNKRKSRESYP---IKH 254
            :|:||:.|.:.||:.:......:||||:|.:..|.:.:|...|::::..|.|  .:.||   ...
Zfish   324 SWRVFVLVCAFPSVAAIAALTTMPESPRFYLENGKHDEAWMILKQVHDTNMR--AKGYPERVFSV 386

  Fly   255 LTDPTPDRSDDLDGTGRPSTLQERFSRAQSKFIDGFKQL----KPMFSSPYLAISLQVYCLHFCQ 315
            .|..|..:.|:|...|..:|...:  |.:.|..:.|.|:    ..:|:..|..|:..:..:.|..
Zfish   387 TTIKTVKQMDELVDMGGEATAWHQ--RWRIKLTNLFHQVWGNFLTVFNPEYRRITYMMMAVWFSM 449

  Fly   316 IMCVNSVRLWLPQIFATMNAMDTLGANDTSMCAVLEH-----------------------NANAK 357
            ......:.:|.|.:...:...:........:...:||                       |...|
Zfish   450 SFSYYGLTVWFPDMIKYLQKQEYSSRTKVFIKEKVEHVTFNFTLENQIHRNGEYFNNKFLNLKMK 514

  Fly   358 SMDEEEKRVECALHHD---PDSYLNNITVAGIGLVGFLIIF---PLMRFQVVSNHILK------- 409
            ||..|:...|.....|   .:::..|.|...       .:|   .|.:::::::.::.
Zfish   515 SMVFEDSLFEECYFEDITSSNTFFRNCTFIS-------TLFYNTDLFKYRLINSKLINSTFLHNK 572

  Fly   410 -------------VFLFICIFL------------------VGSLYFVKTSLVTMMVSAVYLTMMG 443
                         ..::...||                  :|.|..:..|.|...||..:|:...
Zfish   573 EGCMLDFSDENNAYMIYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVISCVSCFFLSFGN 637

  Fly   444 -----ICATTIIG------------MSVVIFPTLMRTMVLLLIMTFGRLGSVSGNMLLPVFMQLS 491
                 |....:.|            ::|.::|:..||.....:....:|.:|.|..:...|:.::
Zfish   638 SESAMIALLCLFGGISIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFQSFVGIT 702

  Fly   492 CLAPFLWLCSLMSIAFLFSLFL 513
            ...|.|:....::.....:|.|
Zfish   703 KAVPILFASGALAAGSFLALKL 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	53/187 (28%)
sv2a	XP_696434.2	synapt_SV2	1..733	CDD:130366	127/607 (21%)
sv2a	XP_696434.2	MFS	162..725	CDD:119392	117/577 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920