DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14691 and sv2ca

DIOPT Version :9

Sequence 1:	NP_650012.2	Gene:	CG14691 / 41287	FlyBaseID:	FBgn0037829	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001121811.1	Gene:	sv2ca / 562345	ZFINID:	ZDB-GENE-060526-233	Length:	745	Species:	Danio rerio

Alignment Length:	571	Identity:	131/571 - (22%)
Similarity:	219/571 - (38%)	Gaps:	127/571 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DRAKDNTDEPADFETAIAECGFGLFN---VFILCSAVPCLTAMVFSASALSYVMPSAECDLDLSI 64
            :|..|..:....:|..|.|||.|.|.   .|.|..|:......||   .:.:|:||||.|:.:..
Zfish   128 ERQADEEELAQQYELIIQECGHGRFQWQLFFTLGLALMSDGVEVF---VVGFVLPSAETDMCVPD 189

  Fly    65 VDKGMLHAVTYAGMIISAVPWGFIADTIGRRPVLISGGWLDGFFVLCASLSQNTAQLMAFKFFDG 129
            ...|.|.::.|.||::.|..||.:||.:|||..|:....|:|||...:|..|.....:..:...|
Zfish   190 SSSGWLGSIVYLGMMVGAFFWGGMADKVGRRQCLLICMSLNGFFAFLSSFVQGYGLFLLCRMIAG 254

  Fly   130 LIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLP-VPILFTVSSM---- 189
            ..|.|...:|.||.||...::.|...:.::.:...||.:....:::.::| ...:.|.||.
Zfish   255 FGIGGAVPIVFSYFAEVLAREKRGEHLSWLCMFWMIGEIYASAMAWAIIPHYGQITTASSQFINY 319

  Fly   190 --------------KFRTWQVFLAVSSAPSLLSGFLHIFLPESPKFLMSQGNYKKALDSLQRIYK 240
                          :|.:|:||:.|.:.|.:.:.....|:||||:|.:..|.:.:|...|::|:.
Zfish   320 HHYTSWSFSMGSAYQFHSWRVFVVVCALPCVCAVVALTFMPESPRFYLEVGKHDEAWMILKQIHD 384

  Fly   241 LNKR---KSRESYPIKHLTDPTPDRSDDLDGTGRPSTLQERFSRAQSKFIDGFKQLKP---MFSS 299
            .|.|   :..:.:.:..:..|                          |.||.|.::..   .||.
Zfish   385 TNMRARGQPEKVFTVNRIKIP--------------------------KQIDEFVEMHESGNFFSK 423

  Fly   300 PYLAISLQVYCLHFCQIMCVN------SVRL---WLPQIFATMNAMDTLGANDTSMC--AVLEHN 353
            ....|..:::.:....:.|.|      :|:|   ||...|         |....|:.  .|::|.
Zfish   424 AIFRIKTELHGIWLNFLKCFNYPVKESTVKLAIVWLTLSF---------GYYGLSVWFPDVIKHL 479

  Fly   354 AN----AKSMDEEEKRVECALHHDPDSYLNNITVAGIGLVGFLII---FPLMRFQVVS--NHILK 409
            .|    :|......:|:|        .:..|.|:........|.|   |..|:|:.|:  |...:
Zfish   480 QNDEYASKGQRHNNERIE--------DFTFNFTLENQIHTNSLFINDRFINMKFKSVTFINSTFQ 536

  Fly   410 VFLFICIFLVGSLY---------FVKTSL-------VTMMVSAVYLTMMGICATTI---IGMSVV 455
            ...|..:..|||.:         |..|.:       ..::.|..|....| |..|.   .....|
Zfish   537 SCFFEDVTSVGSFFRNCTFIEAVFYNTDIDDSKLKNTDVINSTFYHNKTG-CQMTFEDDYSAYWV 600

  Fly   456 IFPTLMRTMVL--------LLIMTFGRLGSVSGNMLLPVFMQLSCLAPFLW 498
            .|...:.|:.:        ||:...|||..:..:|:|   ..:||.  |||
Zfish   601 YFVNFLGTLAVLPGNIVSALLMDKIGRLSMLGFSMIL---SGISCF--FLW 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	53/204 (26%)
sv2ca	NP_001121811.1	synapt_SV2	3..745	CDD:130366	131/571 (23%)
		Spt5_N	73..>141	CDD:288770	2/12 (17%)
		MFS	157..>360	CDD:119392	53/205 (26%)
		MFS	588..>711	CDD:119392	16/64 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920