DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14691 and SLC22A11

DIOPT Version :9

Sequence 1:	NP_650012.2	Gene:	CG14691 / 41287	FlyBaseID:	FBgn0037829	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_060954.1	Gene:	SLC22A11 / 55867	HGNCID:	18120	Length:	550	Species:	Homo sapiens

Alignment Length:	508	Identity:	102/508 - (20%)
Similarity:	189/508 - (37%)	Gaps:	124/508 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PCLTAMVFSASALSYVMPSAECDLDLSIVD-KGMLHAVTYAGMIISAVPWGFIADTIGRRPVLIS 100
            ||:...|:..|..:..: .|:.||..|... |.:..::..:|:::.:..||.::...||:|:|
Human   112 PCVDGWVYDRSVFTSTI-VAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPML-- 173

  Fly   101 GGWLDGFFVLCASLS-QNTAQLMA--FKFFDGLI------ICGPFAVVVSYLAEFHGKKHRPYIM 156
             .|      .|..|: ..|:.:.|  |..:.||.      :.|.|...::.:.|:.....|...|
Human   174 -SW------CCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTM 231

  Fly   157 LFVGLCVSIGSMILPLLSYLLLPVPILFTVSSMKFRTWQVFLAVSSAPSLLSGFLHIFLPESPKF 221
            ..||...|.|...|..|::.|              |.|:.....:|.|......:..:||||.::
Human   232 TVVGCAFSAGQAALGGLAFAL--------------RDWRTLQLAASVPFFAISLISWWLPESARW 282

  Fly   222 LMSQGNYKKALDSLQRIYKLNKRKSRESYPIKHLTDPTPDRSDDLDGTGRPSTLQERFSRAQSKF 286
            |:.:|...:||..|:::.::|..|..::..|:.|.                |:::|..:.|:..
Human   283 LIIKGKPDQALQELRKVARINGHKEAKNLTIEVLM----------------SSVKEEVASAKEP- 330

  Fly   287 IDGFKQLKPMFSSP--------YLAISLQVYCLHFCQIMCVNSVRLWLPQIFATMNAMDTLGAND 343
                :.:..:|..|        .|.::..:...::..:..:.|:...:..:.|...|:|.||...
Human   331 ----RSVLDLFCVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRAT 391

  Fly   344 TSMCAVLEHNANAKSMDEEEKRVECALHHDPDSYLNNITV-AGIGLVGFLIIFPLMRFQVVSNHI 407
            |::..                           |:|...|: ||...:..|.|...|
Human   392 TALLL---------------------------SFLGRRTIQAGSQAMAGLAILANM--------- 420

  Fly   408 LKVFLFICIFLVGSLYFVKTSLVTMMVSAVYLTM----MGICATTIIGMSVVIFPTLMRTMVLLL 468
                            .|...|.|:.|  |:..:    .||..|.:......:|||.:|.....:
Human   421 ----------------LVPQDLQTLRV--VFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGI 467

  Fly   469 IMTFGRLGSVSGNMLLPVFMQLSCLAPFLWLCSLMSIAFLFSLFLKVDDEQSL 521
            :.|.||||::.|.::|.....|..|.|.|:  .::|||....:...:.:.|.|
Human   468 LHTVGRLGAMMGPLILMSRQALPLLPPLLY--GVISIASSLVVLFFLPETQGL 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	40/188 (21%)
SLC22A11	NP_060954.1	Sugar_tr	11..523	CDD:331684	102/508 (20%)
SLC22A11	NP_060954.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153212
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850