DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14691 and slc22a16

DIOPT Version :9

Sequence 1:	NP_650012.2	Gene:	CG14691 / 41287	FlyBaseID:	FBgn0037829	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001020659.1	Gene:	slc22a16 / 557279	ZFINID:	ZDB-GENE-041001-166	Length:	565	Species:	Danio rerio

Alignment Length:	518	Identity:	116/518 - (22%)
Similarity:	185/518 - (35%)	Gaps:	166/518 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PCLTAM----------------VFSASALSY----VMPSAECDLDLSIVDKGMLHAVT----YAG 77
            |||.|:                |.|..|..|    |..|...|.|| :.::..|..:|    ..|
Zfish    98 PCLKALRLDAINFQYEFFGNKSVESCGAFVYDHSEVEQSIVTDWDL-VCEREWLAKLTQPTFMLG 161

  Fly    78 MIISAVPWGFIADTIGRRPVLISGGWLDGFFVLCASLSQNTAQLMAFKFFDGLIICGPFAVVVSY 142
            ::|.|:.:|..||.|||||||::.......|.:..:.:.|....:..:|....:..|...||..|
Zfish   162 VLIGALMFGDAADRIGRRPVLMATSLCQFIFGVTVAFTGNYYLFVVMRFLLATVSSGYLVVVFVY 226

  Fly   143 LAEFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLPVPILFTVSSMKFRTW---QVFLAVSSAP 204
            :.||.|.|.|.:..:.|....::|.|::.|:.||:              |.|   |:.|.:|::|
Zfish   227 VTEFTGIKVRTWTSMHVHAAFAVGIMVVALVGYLV--------------RVWWIYQIILTLSTSP 277

  Fly   205 SLLSGFLHIFLPESPKFLMSQGNYKKALDSLQRIYKLNKRKSRESYPIKHLTDPTPDRSDDLDGT 269
            .||..:.   .||:|.:||::|.||:|.:.|..:..:|      ..|      ||...||..||.
Zfish   278 FLLYCWK---FPETPFYLMAKGRYKEAQELLDTMAYIN------GLP------PTLKVSDLQDGC 327

  Fly   270 GRPSTLQERFSRAQSK---FIDGFKQLKPMFSSPYLAISLQVYCLHFCQIMCVNSVRLWLPQIFA 331
            .|......:.:....|   .:|.|..||                      |...|...|......
Zfish   328 DRTPLKDNKQAMEVEKRLSMLDMFGSLK----------------------MAGRSATCWAIWFIG 370

  Fly   332 TMN------AMDTLGANDTSMCAVLEHNANAKSMDEEEKRVECALHHDPDSYLNNITVAGIGLVG 390
            ::.      ....||.|                                 .|:|......:.:..
Zfish   371 SLGYYVFSLGSVNLGGN---------------------------------QYINLFLAGAVEVPS 402

  Fly   391 FLI-IFPLMRFQVVSNHILKVFLFIC--IFLVGSLYFVKTSLVTMM-----VSAVYLTMMGICAT 447
            :|| .|.:.||.....         |  ..|:|.   |...|:.::     |.|:.|:|.|..|.
Zfish   403 YLIGCFAMDRFGRKKT---------CAPALLLGG---VACMLIIVVPQDVEVLAIVLSMTGKFAI 455

  Fly   448 TI-IGM----SVVIFPTLMRTMVLLLIMTFGRLGSVSGNMLLPVFMQLSCLAPF------LWL 499
            .| .|:    :..::||::|::.:           .||:|:..|.   |.:|||      :|:
Zfish   456 AIAFGLIYLYTCELYPTIIRSLAV-----------GSGSMMCRVG---SVVAPFCVYLADIWI 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	54/205 (26%)
slc22a16	NP_001020659.1	2A0119	13..536	CDD:273328	116/518 (22%)
slc22a16	NP_001020659.1	MFS	158..526	CDD:119392	101/457 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850