Protein Alignment CG14691 and SLC22A17

DIOPT Version :10

• Sequence 1: NP_650012.2
• Gene: CG14691 / 41287
• FlyBaseID: FBgn0037829
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_065105.3
• Gene: SLC22A17 / 51310
• HGNCID: 23095
• Length: 649
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 105/536 - (19%)
• Similarity: 197/536 - (36%)
• Gaps: 119/536 - (22%)

  Fly     2 ADRAKDNTD------EPADFETAIAECGFGLFNVFILCSAVPCLTAMVFSASALSYVMPSAECDL 60
            |.|...:||      .|.||...:.:..:         :.:|.||........|       .|||
Human   159 ASRVATSTDPSCSGFAPPDFNHCLKDWDY---------NGLPVLTTNAIGQWDL-------VCDL 207

  Fly    61 DLSIVDKGMLHAVTYAGMIISAVPWGFIADTIGRRPVLISGGWLDGFFVLCASLSQNTAQLMAFK 125
            ...::.:.:|..:.:|...:..   |:.||..|||.:::....|.|...:..:.:.::..:||.:
Human   208 GWQVILEQILFILGFASGYLFL---GYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALR 269

  Fly   126 FFDGLIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLPVPILFTVSSMK 190
            |..|.::.|....|.....|......|..:.| .|..|.:|.             ..||...::.
Human   270 FLLGFLLAGVDLGVYLMRLELCDPTQRLRVAL-AGELVGVGG-------------HFLFLGLALV 320

  Fly   191 FRTWQVFLAVSSAPSLL---SGFLHIFLPESPKFLMSQGNYKKALDSLQRIYKLNKRKSRESYPI 252
            .:.|:....:.:||.:|   .|:..:|| ||.::|:    .|:.::..|.:.::...::|....:
Human   321 SKDWRFLQRMITAPCILFLFYGWPGLFL-ESARWLI----VKRQIEEAQSVLRILAERNRPHGQM 380

  Fly   253 KHLTDPTPDRSDDLDGT-GRPSTLQERFSRAQSKFIDGFKQLKPMFSSPYLAISLQVYCLHFCQI 316
              |.:...:...||:.| ..|:|....|:...:                |..|...:..|.|...
Human   381 --LGEEAQEALQDLENTCPLPATSSFSFASLLN----------------YRNIWKNLLILGFTNF 427

  Fly   317 MCVNSVRLWLPQIFATMNAMDTLGA----NDTSMCAVLEHNANAKSMDEEEKRVECALHHDPDSY 377
            :.           .|..:....:|.    :|..:|::|.....|         :.|.       :
Human   428 IA-----------HAIRHCYQPVGGGGSPSDFYLCSLLASGTAA---------LACV-------F 465

  Fly   378 LNNITVAGIGLVGFLIIFPLMRFQVVSNHILKVFLFICIFLVGSLYFV----------KTSLVTM 432
            | .:||...|..|.|::  .|....:::.:| :.|:.|...:....:.          :.::.|.
Human   466 L-GVTVDRFGRRGILLL--SMTLTGIASLVL-LGLWDCEHPIFPTVWAQQGNPNRDLNEAAITTF 526

  Fly   433 MVSAVYLTMMGICATTIIGMSVVIFPTLMRTMVLLLIMTFGRLGSVSG-----NMLLPVFMQLSC 492
            .|..::.:......:|::...|:  ||.:|...|.|||..|.||.:||     :|....|:|...
Human   527 SVLGLFSSQAAAILSTLLAAEVI--PTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVV 589

  Fly   493 LAPFLWLCSLMSIAFL 508
            ||....|| ::||..|
Human   590 LAACALLC-ILSIMLL 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	synapt_SV2	2..>337	CDD:130366	63/344 (18%)
		MFS	<375..513	CDD:475125	36/149 (24%)
SLC22A17	NP_065105.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..70
		MFS_SLC22A17	174..605	CDD:341003	101/521 (19%)