DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14691 and CG31103

DIOPT Version :9

Sequence 1:	NP_650012.2	Gene:	CG14691 / 41287	FlyBaseID:	FBgn0037829	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001097914.1	Gene:	CG31103 / 43030	FlyBaseID:	FBgn0051103	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	135/529 - (25%)
Similarity:	258/529 - (48%)	Gaps:	64/529 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADRAKDNTDEPA--DFETAIAECGFGLFN-VFILCSAVPCLTAMVFSASALSYVMPSAECDLDL 62
            |....:.||..|.  |::..:.:.|:|... |.:|.|.:..:|: |.:..|:|.::.:::|:.:.
  Fly     1 MHSSLESNTLGPNVWDYDMVLEKIGYGKTQWVLLLVSGLLTITS-VAAQQAMSIIVIASQCEFET 64

  Fly    63 SIVDKGMLHAVTYAGMIISAVPWGFIADTIGRRPVLISGGWLDGF--FVLCASLSQ---NTAQLM 122
            :..:||::.|.:..|:.:|...||:|:|.||||.||:.|.:....  |||....|.   |...|:
  Fly    65 TQAEKGVMMAASVTGIFLSTYIWGYISDDIGRRRVLLYGNFASNALQFVLMFVTSVWLFNIINLL 129

  Fly   123 AFKFFDGLIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLPVPILFTVS 187
            .     |:.:....|.:.:||:||:..:||...:.:..:.||:.::.:|..::|:|......|:.
  Fly   130 V-----GISVGAVSAALYAYLSEFNIPRHRAVAINYSTMFVSVTAIYVPATAWLVLSSNWAITMG 189

  Fly   188 SMKFRTWQVFLAVSSAPSLLSGFLHIFLPESPKFLMSQGNYKKALDSLQRIYKLNKRK------S 246
            ...||.|::.|.||..|..:.|.:.::.|||||||:||....:|::::..|.|.|:.|      |
  Fly   190 DFVFRPWRLLLLVSLLPGFIGGLILLYYPESPKFLLSQEKNNEAIEAVAWISKFNRGKSIQQVLS 254

  Fly   247 RESYPIKHLTDPTPDRSDDLDGTGRPSTLQERFSRAQSKFIDGFKQLKPMFSSP----YLAISLQ 307
            .:.:.:|. .||.   .::|.|..:...:..:..||..          |:|..|    ::..:|.
  Fly   255 CDEFTLKS-EDPV---GENLLGESQGCGILSKICRATI----------PLFHKPHGFNFILCNLA 305

  Fly   308 VYCLHFCQIMCVNSVRLWLPQIFATMNAMDTLGANDTSMCAVLEHNANAKSMDEEEKRVECALHH 372
            ::.:.|..    |.::||.|:|   :|.......|.:::|.:|.......::.|   .::|.
  Fly   306 LFGMFFSS----NGMQLWFPEI---VNRSSGAENNSSTVCEILSVPVEQPNVTE---TLDCT--- 357

  Fly   373 DPDS---YLNNITVAGIGLVGF----LIIFPLMRFQVVSNHILKVFLFICIFLVGSLYFVKTSLV 430
            ||.|   |::|:.|....|:||    ||:.||.|     .::|...|.:.......|:|:::...
  Fly   358 DPISSKTYIDNLVVGFAFLIGFSIQGLILNPLGR-----KNVLLAALAVATLSGVLLHFMESPTG 417

  Fly   431 TMMVSAVYLTMMGICATTIIGMSVVIFPTLMRTMVLLLIMTFGRLGSVSGNMLLPVFMQLSCLAP 495
            .:::..:|:.:.|:..:.:||..|.:.||.:|:..:...|:.||||.::...|:.|.:|..|...
  Fly   418 VLVLFCLYILLPGLSISIMIGAIVDLVPTHLRSKAVSFCMSLGRLGIIAATNLMGVMLQPYCNTT 482

  Fly   496 F-LWLCSLM 503
            | ::.|:|:
  Fly   483 FAMFTCTLI 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	51/190 (27%)
CG31103	NP_001097914.1	2A0115	29..475	CDD:273327	123/483 (25%)
CG31103	NP_001097914.1	MFS	34..>189	CDD:119392	43/160 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458190
Domainoid	1	1.000	77	1.000	Domainoid score	I3080
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I296
Isobase	1	0.950	-	0	Normalized mean entropy	S5294
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.950