DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14691 and Slc22a20

DIOPT Version :9

Sequence 1:	NP_650012.2	Gene:	CG14691 / 41287	FlyBaseID:	FBgn0037829	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_941052.1	Gene:	Slc22a20 / 381203	MGIID:	2685809	Length:	556	Species:	Mus musculus

Alignment Length:	515	Identity:	101/515 - (19%)
Similarity:	185/515 - (35%)	Gaps:	176/515 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 CLTAMVFSASALSYVMPSA---ECDL--------DLSIVDKGMLHAVTYAGMIISAVPWGFIADT 91
            |....|:..|    :.||.   |.||        ||:       .::..:|:::.|..:|.:||.
Mouse   107 CKDGWVYDRS----IFPSTIVMEWDLVCEARTLRDLA-------QSIYMSGVLVGAALFGGLADR 160

  Fly    92 IGRRPVL--------ISG---GWLDGFFVLCASLSQNTAQLMAFKFFDGLIICGPFAVVVSYLAE 145
            :||:..|        :||   .::..|...|           .|:|..|:...|.....:|.:.|
Mouse   161 LGRKAPLVWSYLQLAVSGAATAYVGSFSAYC-----------VFRFLMGMTFSGIILNSLSLVVE 214

  Fly   146 FHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLPVPILFTVSSMKFRTWQVFLAVSSAPSLLSGF 210
            :...:.|....:.:|...::|.:||..::||:.|              |:......|||.|:...
Mouse   215 WMPTRGRTVAGILLGFSFTLGQLILAGVAYLIRP--------------WRWLQFAVSAPFLVFFL 265

  Fly   211 LHIFLPESPKFLMSQGNYKKALDSLQRIYKLNKRKSRESYPIKHLTDPTPDRSDDLDGTGRPSTL 275
            ...:||||.::|:..|..::|:.:||::..:|.||:..    :.||.....           |.:
Mouse   266 YSWWLPESSRWLLLHGKAQQAVQNLQKVAMMNGRKAEG----ERLTTEVVS-----------SYI 315

  Fly   276 QERFS--RAQSKFIDGFKQ----------LKPMFSSPY----LAISLQVYCLHFCQIMCVNSVRL 324
            |:.|:  |..:..:|.|:.          :...||:..    ||:.||.:.|....:..:..: :
Mouse   316 QDEFASVRTSNSILDLFRTPAIRRVTCCLMGVWFSNSVAYYGLAMDLQKFGLSIYLVQALFGI-I 379

  Fly   325 WLPQIFATMNAMDTLGANDTSMCAVLEHNANAKSMDEEEKRVECALHHDPDSYLNNITVAGIGLV 389
            .:|.:......|..:|...|                                           :.
Mouse   380 DIPAMLVATTTMIYVGRRAT-------------------------------------------VS 401

  Fly   390 GFLIIFPLMRFQVVSNHILKVFL------------------FICIFL-VGSLYFVKTSLVTMMVS 435
            .|||:..||   |::|..:...|                  |||::| .|.||..:...:.|..:
Mouse   402 SFLILAGLM---VIANMFMPEDLQTLRTVQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFA 463

  Fly   436 AVYLTMMGICA---TTIIGMSVVIFPTLMRTMVLLLIMTFGRLGSVSGNMLLPVFMQLSC 492
            :|...:.|:.|   ||:..:|.|:.|           ::||....::|       |.::|
Mouse   464 SVNARLGGLVAPLITTLGEISPVLPP-----------VSFGATSVLAG-------MAVAC 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	41/199 (21%)
Slc22a20	NP_941052.1	2A0119	11..518	CDD:273328	101/515 (20%)
		MFS	138..507	CDD:119392	92/480 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..556
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843537
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850