DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14691 and Slc22a17

DIOPT Version :9

Sequence 1:	NP_650012.2	Gene:	CG14691 / 41287	FlyBaseID:	FBgn0037829	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_803156.2	Gene:	Slc22a17 / 305886	RGDID:	631405	Length:	520	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	104/528 - (19%)
Similarity:	191/528 - (36%)	Gaps:	121/528 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ADRAKDNTD------EPADFETAIAECGFGLFNVFILCSAVPCLTAMVFSASALSYVMPSAECDL 60
            |.|...:||      .|.||...:.:..:         :.:|.||........|       .|||
  Rat    48 ASRVVTSTDPSCSGFAPPDFNHCLKDWDY---------NGLPVLTTNAIGQWDL-------VCDL 96

  Fly    61 DLSIVDKGMLHAVTYAGMIISAVPWGFIADTIGRRPVLISGGWLDGFFVLCASLSQNTAQLMAFK 125
            ...::.:.:|..:.:|...:..   |:.||..|||.:::....|.|...:..:.:.::..:|..:
  Rat    97 GWQVILEQILFILGFASGYLFL---GYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGIMTLR 158

  Fly   126 FFDGLIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLPVPILFTVSSMK 190
            |..|.::.|....|.....|......|..:.| .|..|.:|.             ..||...::.
  Rat   159 FLLGFLLAGVDLGVYLMRLELCDPTQRLRVAL-AGELVGVGG-------------HFLFLGLALV 209

  Fly   191 FRTWQVFLAVSSAPSLL---SGFLHIFLPESPKFLMSQGNYKKALDSLQRIYKLNKRKSRESYPI 252
            .:.|:....:.:||.:|   .|:..:|| ||.::|:    .|:.::..|.:.::...::|....:
  Rat   210 SKDWRFLQRMITAPCILFLFYGWPGLFL-ESARWLI----VKRQIEEAQSVLRILAERNRPHGQM 269

  Fly   253 KHLTDPTPDRSDDLDGTGRPSTLQERFSRAQSKFIDGFKQLKPMFSS--PYLAISLQVYCLHFCQ 315
              |.:...:...:|:.| .|......||                |:|  .|..|...:..|.|..
  Rat   270 --LGEEAQEALQELENT-CPLPTTSTFS----------------FASLLNYRNIWKNLLILGFTN 315

  Fly   316 IMCVNSVRLWLPQIFATMNAMDTLGA----NDTSMCAVLEHNANAKSMDEEEKRVECALHHDPDS 376
            .:.           .|..:....:|.    :|..:|::|.....|         :.|.
  Rat   316 FIA-----------HAIRHCYQPVGGGGSPSDFYLCSLLASGTAA---------LACV------- 353

  Fly   377 YLNNITVAGIGLVGFLIIFPLMRFQVVSNHILKVFLFICIFLVGSL-YFVKTSLVTMMVSAVYLT 440
            :| .:||...|..|.|::  .|....:::          :.|:|.. |....::.|..|..::.:
  Rat   354 FL-GVTVDRFGRRGILLL--SMTLTGIAS----------LVLLGLWDYLNDAAITTFSVLGLFSS 405

  Fly   441 MMGICATTIIGMSVVIFPTLMRTMVLLLIMTFGRLGSVSG-----NMLLPVFMQLSCLAPFLWLC 500
            ......:|::...|:  ||.:|...|.|||..|.||.:|.     :|....|:|...||....||
  Rat   406 QASAILSTLLAAEVI--PTTVRGRGLGLIMALGALGGLSCPAQRLHMGHGAFLQHVVLAACALLC 468

  Fly   501 SLMSIAFL 508
             ::||..|
  Rat   469 -ILSIMLL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	36/188 (19%)
Slc22a17	NP_803156.2	MFS	106..476	CDD:119392	90/454 (20%)
Slc22a17	NP_803156.2	2A0114	111..475	CDD:273326	88/447 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346890
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930