Protein Alignment CG14691 and Sv2c

DIOPT Version :9

• Sequence 1: NP_650012.2
• Gene: CG14691 / 41287
• FlyBaseID: FBgn0037829
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_113781.1
• Gene: Sv2c / 29643
• RGDID: 619718
• Length: 727
• Species: Rattus norvegicus
• Alignment Length: 553
• Identity: 129/553 - (23%)
• Similarity: 217/553 - (39%)
• Gaps: 105/553 - (18%)

  Fly     2 ADRAKDNTDEPADFETAIAECGFGLFN---VFILCSAVPCLTAMVFSASALSYVMPSAECDLDLS 63
            ::|..|..:....:|..|.|||.|.|.   .|:|..|:......||   .:.:|:||||.||.:.
  Rat   125 SERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVF---VVGFVLPSAETDLCIP 186

  Fly    64 IVDKGMLHAVTYAGMIISAVPWGFIADTIGRRPVLISGGWLDGFFVLCASLSQNTAQLMAFKFFD 128
            ....|.|.::.|.||::.|..||.:||.:||:..|:....::|||...:|..|.....:..:...
  Rat   187 NSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLLCRLLS 251

  Fly   129 GLIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLP-VPILFTV-SSMKF 191
            |..|.|....|.||.||...::.|...:.::.:...||.:....:::.::| ....|:: |:.:|
  Rat   252 GFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQF 316

  Fly   192 RTWQVFLAVSSAPSLLSGFLHIFLPESPKFLMSQGNYKKALDSLQRIYKLNKRKSRESYPIKHLT 256
            .:|:||:.|.:.|.:.|.....|:||||:||:..|.:.:|...|:.|:..|.|  ....|.|..|
  Rat   317 HSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMR--ARGQPEKVFT 379

  Fly   257 ---DPTPDRSDDL----DGTGRPSTLQER-FSRAQSKFIDGFKQLKPMFSSPYLAISLQVYCLHF 313
               ..||.:.|:|    ..||   |...| |.|.:::....:......|:.|....::::..:.|
  Rat   380 VNKIKTPKQIDELIEIESDTG---TWYRRCFVRIRTELYGIWLTFMRCFNYPVRENTIKLTIVWF 441

  Fly   314 CQIMCVNSVRLWLPQIFATMNAMDTLGANDTSMCAVLEHN------ANAKSMDEEEKRVECALHH 372
            ........:.:|.|.:...:.:.:         .|:|..|      ||.......|.:|...:.:
  Rat   442 TLSFGYYGLSVWFPDVIKHLQSDE---------YALLTRNVQKDKYANFSINFTMENQVHTGMEY 497

  Fly   373 D--------------PDSYLNNITVAGIGLVGFLIIFPLMRF--QVVSNHILKVFLFI------C 415
            |              .||...:.|...:..|.  ..|....|  .:..|...:.:.||      |
  Rat   498 DNGRFLGVKFKSVTFKDSVFKSCTFDDVTSVN--TYFKNCTFIDTLFENTDFEPYKFIDSEFQNC 560

  Fly   416 IFLVGS---------------LYFVKTSLVTMMVSAVYLTMMGICATTIIGMSVVIFPTLMRTMV 465
            .||...               :|||.           :|..:.:....|:.
  Rat   561 SFLHNKTGCQITFDDDYSAYWIYFVN-----------FLGTLAVLPGNIVS-------------- 600

  Fly   466 LLLIMTFGRLGSVSGNMLLPVFMQLSCLAPFLW 498
            .||:...|||..:.|:|:|   ..:||.  |||
  Rat   601 ALLMDRIGRLTMLGGSMVL---SGISCF--FLW 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	52/187 (28%)
Sv2c	NP_113781.1	synapt_SV2	1..727	CDD:130366	129/553 (23%)
		Interaction with SYT1. /evidence=ECO:0000269|PubMed:15866046	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..120
		MFS	155..719	CDD:119392	120/523 (23%)
		Pentapeptide_3	507..561	CDD:290309	9/55 (16%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:16543415, ECO:0000269|PubMed:27294781	529..566		8/38 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920