DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14691 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_650012.2	Gene:	CG14691 / 41287	FlyBaseID:	FBgn0037829	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	91/489 - (18%)
Similarity:	174/489 - (35%)	Gaps:	140/489 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PCLTAMVFSASALSYVMPS---AECDLDLS-IVDKGMLHAVTYAGMIISAVPWGFIADTIGRRPV 97
            ||:...|:..|    ..||   .|.:|..| ...:.:..::...|:::.|:.:|::||.:|||.|
  Rat   104 PCIDGWVYDNS----TFPSTIVTEWNLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKV 164

  Fly    98 LISGGWLDGFFVLCASLSQNTAQLMAFKFFDGLIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLC 162
            ||...........||:.:.|......|:...|:.:.......::...|:.....|.|:...:|..
  Rat   165 LILNYLQTAVSGTCAAYAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHTRAYVGTLIGYV 229

  Fly   163 VSIGSMILPLLSYLLLPVPILFTVSSMKFRTWQVFLAVSSAPSLLSGFLHIFLPESPKFLMSQGN 227
            .|:|..:|..::|   .||           .|:....|.|.|..::.....|..||.::..|.|.
  Rat   230 YSLGQFLLAGIAY---AVP-----------HWRHLQLVVSVPFFIAFIYSWFFIESARWYSSSGR 280

  Fly   228 YKKALDSLQRIYKLN-KRKSRESYPIKHLTDPTPDRSDDLDGTGRPSTLQE-RFSRAQSKFIDGF 290
            ....|.:|||:.::| |::......|:.|               |.|..:| ..|:.|:..::..
  Rat   281 LDLTLRALQRVARINGKQEEGAKLSIEVL---------------RTSLQKELTLSKGQASAMELL 330

  Fly   291 KQLKPMFSSPYLAISLQVYCLHFCQIMCVNSVRLWLPQIFATMNAMDTLGANDTSMCAVLEHNAN 355
            :  .|.....:|.:|:                 ||....||....:
  Rat   331 R--CPTLRHLFLCLSM-----------------LWFATSFAYYGLV------------------- 357

  Fly   356 AKSMDEEEKRVECALHHDPDSYLNNITVAGIGLVGFLIIFPLMRFQVVSNHILKVFLFICIFLVG 420
               ||                      :.|.|:..:||       ||:...:.....|:|..::.
  Rat   358 ---MD----------------------LQGFGVSMYLI-------QVIFGAVDLPAKFVCFLVIN 390

  Fly   421 SLYFVKTSLVTMMVSAVYLTMMGIC--ATTIIGMSVVI--------------------FPTLMRT 463
            |:......:.:::::.:.:.:.||.  :.|||..|:.:                    :||::|.
  Rat   391 SMGRRPAQMASLLLAGICILVNGIIPKSHTIIRTSLAVLGKGCLASSFNCIFLYTGELYPTVIRQ 455

  Fly   464 MVLLLIMTFGRLGSVSGNML---------LPVFM 488
            ..|.:..|..|:||:...::         :|:|:
  Rat   456 TGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFI 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	40/182 (22%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	91/489 (19%)
		MFS	135..505	CDD:119392	82/454 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347183
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850