Protein Alignment CG14691 and Slc22a1

DIOPT Version :10

• Sequence 1: NP_650012.2
• Gene: CG14691 / 41287
• FlyBaseID: FBgn0037829
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_036829.1
• Gene: Slc22a1 / 24904
• RGDID: 3224
• Length: 556
• Species: Rattus norvegicus
• Alignment Length: 534
• Identity: 99/534 - (18%)
• Similarity: 197/534 - (36%)
• Gaps: 157/534 - (29%)

  Fly    12 PADFETAIAECGFGLFNVFILCSAVPC---LTAMVFSASALS---------YVMPSAECDLDLSI 64
            |:|..:.:::|  ..:.|....|.:.|   |:::|.:.|.|.         |..|.:....:.::
  Rat    79 PSDEASFLSQC--MRYEVDWNQSTLDCVDPLSSLVANRSQLPLGPCEHGWVYDTPGSSIVTEFNL 141

  Fly    65 V-----DKGMLHAVTYAGMIISAVPWGFIADTIGRRPVL--------ISGGWLDGFFVLCASLSQ 116
            |     ...:..:....|..:.::..|:|||..||:..|        :||       ||.|....
  Rat   142 VCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVSG-------VLTAVAPD 199

  Fly   117 NTAQLMAFKFFDGLIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLPVP 181
            .|:.|: |:...|::..|.:....:.:.||.|..:|....:...:..::|.:.|..::|   .:|
  Rat   200 YTSMLL-FRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLVGLAGVAY---AIP 260

  Fly   182 ILFTVSSMKFRTWQVFLAVSSAPSLLSGFLHIFLPESPKFLMSQGNYKKALDSLQRIYKLNKRKS 246
                       .|:......|.|:.|....:.|:||||::|:||....:|:..:::|.:.|.:.
  Rat   261 -----------DWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKV- 313

  Fly   247 RESYPIKHLTDPTPDRSDDLDGTGRPSTLQERFSRAQS-KFIDGFKQLKPMFSSPYLA--ISLQV 308
                       |..|.        :...|:|..|..:| .|.|       :|.:|.|.  ..:.:
  Rat   314 -----------PPADL--------KMLCLEEDASEKRSPSFAD-------LFRTPNLRKHTVILM 352

  Fly   309 YCLHFCQIMCVNSVRLWLPQIFATMNAMDTLGAN---DTSMCAVLEHNANAKSMDEEEKRVECAL 370
            |....|.::....:.    .:.||       |||   |....:::|.
  Rat   353 YLWFSCAVLYQGLIM----HVGAT-------GANLYLDFFYSSLVEF------------------ 388

  Fly   371 HHDPDSYLNNITVAGIGLVGFLIIFPLMRFQVVSNHILKVFLFICIFLVGSLYFVKTSLVTMMVS 435
               |.:::..:|:..||.     |:|:    ..||.:......:.||:...|:::..:|..:...
  Rat   389 ---PAAFIILVTIDRIGR-----IYPI----AASNLVTGAACLLMIFIPHELHWLNVTLACLGRM 441

  Fly   436 AVYLTMMGICATTIIGMSVVIFPTLMRTMVLLL---------------------------IMTFG 473
            ...:.:..:|.     ::..::||.:|.:.:::                           ::.||
  Rat   442 GATIVLQMVCL-----VNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFG 501

  Fly   474 RLGSVSGNM--LLP 485
            .||..:|.|  |||
  Rat   502 VLGLTAGAMTLLLP 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	synapt_SV2	2..>337	CDD:130366	69/352 (20%)
		MFS	<375..513	CDD:475125	24/140 (17%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	99/534 (19%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15245	284..288		3/3 (100%)