DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14691 and SV2C

DIOPT Version :10

Sequence 1:NP_650012.2 Gene:CG14691 / 41287 FlyBaseID:FBgn0037829 Length:522 Species:Drosophila melanogaster
Sequence 2:NP_055794.3 Gene:SV2C / 22987 HGNCID:30670 Length:727 Species:Homo sapiens


Alignment Length:617 Identity:131/617 - (21%)
Similarity:236/617 - (38%) Gaps:128/617 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ADRAKDNTDEPADFETAIAECGFGLFN---VFILCSAVPCLTAMVFSASALSYVMPSAECDLDLS 63
            ::|..|..:....:|..|.|||.|.|.   .|:|..|:......||   .:.:|:||||.||.:.
Human   125 SERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVF---VVGFVLPSAETDLCIP 186

  Fly    64 IVDKGMLHAVTYAGMIISAVPWGFIADTIGRRPVLISGGWLDGFFVLCASLSQNTAQLMAFKFFD 128
            ....|.|.::.|.||::.|..||.:||.:||:..|:....::|||...:|..|.....:..:...
Human   187 NSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLS 251

  Fly   129 GLIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLP-VPILFTV-SSMKF 191
            |..|.|....|.||.||...::.|...:.::.:...||.:....:::.::| ....|:: |:.:|
Human   252 GFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQF 316

  Fly   192 RTWQVFLAVSSAPSLLSGFLHIFLPESPKFLMSQGNYKKALDSLQRIYKLNKRKSRESYPIKHLT 256
            .:|:||:.|.:.|.:.|.....|:||||:||:..|.:.:|...|:.|:..|.|  ....|.|..|
Human   317 HSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMR--ARGQPEKVFT 379

  Fly   257 ---DPTPDRSDDL----DGTGRPSTLQER-FSRAQSKFIDGFKQLKPMFSSPYLAISLQVYCLHF 313
               ..||.:.|:|    ..||   |...| |.|.:::....:......|:.|....::::..:.|
Human   380 VNKIKTPKQIDELIEIESDTG---TWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWF 441

  Fly   314 CQIMCVNSVRLWLPQI------------------------------------------------- 329
            ........:.:|.|.:                                                 
Human   442 TLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVK 506

  Fly   330 ---------------FATMNAMDTLGANDTSMCAVLEHN--ANAKSMDEEEKRVECALHHD---- 373
                           |..:.:::|...|.|.:..|.::.  ...|.:|.|.|  .|:..|:    
Human   507 FKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFK--NCSFFHNKTGC 569

  Fly   374 ----PDSYLNNITVAGIGLVGFLIIFPLMRFQVVSNHILKVFLFICIFLVGSLYFVKTSLVTMMV 434
                .|.| :...:..:..:|.|.:.|        .:|:...|   :..:|.|..:..|:|...:
Human   570 QITFDDDY-SAYWIYFVNFLGTLAVLP--------GNIVSALL---MDRIGRLTMLGGSMVLSGI 622

  Fly   435 SAVYLTMMGICATTIIGM------------------SVVIFPTLMRTMVLLLIMTFGRLGSVSGN 481
            |..:| ..|...:.:|||                  :|.::||..|......:....:..:|.||
Human   623 SCFFL-WFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGN 686

  Fly   482 MLLPVFMQLSCLAPFLWLCSLMSIAFLFSLFL 513
            ::....:.::...|.|...:::....|..|.|
Human   687 LIFGSLVSITKSIPILLASTVLVCGGLVGLCL 718

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14691NP_650012.2 synapt_SV2 2..>337 CDD:130366 92/411 (22%)
MFS <375..513 CDD:475125 28/155 (18%)
SV2CNP_055794.3 synapt_SV2 1..727 CDD:130366 131/617 (21%)
Interaction with SYT1. /evidence=ECO:0000250 1..57
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..84
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..128 0/2 (0%)
(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:27294781 519..563 10/45 (22%)
Blue background indicates that the domain is not in the aligned region.

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