Protein Alignment CG14691 and SLC22A31

DIOPT Version :10

• Sequence 1: NP_650012.2
• Gene: CG14691 / 41287
• FlyBaseID: FBgn0037829
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_001371692.1
• Gene: SLC22A31 / 146429
• HGNCID: 27091
• Length: 446
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 93/485 - (19%)
• Similarity: 162/485 - (33%)
• Gaps: 177/485 - (36%)

  Fly    77 GMIISAVPWGFIADTIGRRPVLISGGWLDGFFVLCASLSQNTA------QLMAFKFFDGLIICGP 135
            |.::..|..|...|..|||.|.::.      .||...|..:.|      .|:..:...|..:.|
Human    29 GWLLGCVILGAGCDRFGRRAVFVAS------LVLTTGLGASEALAASFPTLLVLRLLHGGTLAG- 86

  Fly   136 FAVVVSYLA--EFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLPVPILFTVSSMKFRTWQVFL 198
             |::..|||  |.....||....:..||...:|:::||.|:.|:              :.|::..
Human    87 -ALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALV--------------QDWRLLQ 136

  Fly   199 AVSSAPSLLSGFLHIF------LPESPKFLMSQGNYKKALDSLQRIYKLNKRKSRESYPIKHLTD 257
            .:.   :|:||.|.:|      .||||.:|::.|...:|...|.|.
Human   137 GLG---ALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRF------------------- 179

  Fly   258 PTPDRSDDLDGTGRPSTLQERFSRAQSKFIDGFKQLKPMFSSPYLAISLQV-----YCLHFCQI- 316
                  .:..|.|...:..|..|.|....:...:..:|.:.||...:..:|     ..|.|..:
Human   180 ------AEASGVGPGDSSLEENSLATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLV 238

  Fly   317 ---MCVNSVRLWLPQIFATMNAMDTLGANDTSMCAVLEHNANAKSMDEEEKRVECALHHDPDSYL 378
               :..:..|...||:                                            |..||
Human   239 GGGIRASFRRSLAPQV--------------------------------------------PTFYL 259

  Fly   379 NNITVAGIGLVGFLIIFPLMRFQVVSNHILKVFLFI----C----IFLVGSLYFVKTSLVTMMVS 435
            .....||:.....                  |||.:    |    :.|:|::.   |.|.::::.
Human   260 PYFLEAGLEAAAL------------------VFLLLTADCCGRRPVLLLGTMV---TGLASLLLL 303

  Fly   436 A----------VYLTMMGICATTIIG-----MSVVIFPTLMRTMVLLLIMTFGRLGSVSGNMLLP 485
            |          ::|:::|:.|:..:.     .:..:|||::|...|.|::..|.||..:|    |
Human   304 AGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAG----P 364

  Fly   486 V---------FMQ---LSCLAPFLWLCSLM 503
            :         |:|   .:.||....||.|:
Human   365 LDTLHGRQGFFLQQVVFASLAVLALLCVLL 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	synapt_SV2	2..>337	CDD:130366	58/282 (21%)
		MFS	<375..513	CDD:475125	34/164 (21%)
SLC22A31	NP_001371692.1	MFS	9..383	CDD:475125	88/472 (19%)