Protein Alignment CG14691 and Sv2b

DIOPT Version :9

• Sequence 1: NP_650012.2
• Gene: CG14691 / 41287
• FlyBaseID: FBgn0037829
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_476555.1
• Gene: Sv2b / 117556
• RGDID: 619716
• Length: 683
• Species: Rattus norvegicus
• Alignment Length: 613
• Identity: 133/613 - (21%)
• Similarity: 253/613 - (41%)
• Gaps: 103/613 - (16%)

  Fly     1 MADRAKDNTDEPADFETAIAECGFGLFN---VFILCSAVPCLTAMVFSASALSYVMPSAECDLDL 62
            ||:|.:|.......:||.|.|||.|.|.   .|:|..|:......||   .:|:.:||||.|:.|
  Rat    81 MAERMEDEEQLAHQYETIIDECGHGRFQWTLFFVLVLALMADGVEVF---VVSFALPSAEKDMCL 142

  Fly    63 SIVDKGMLHAVTYAGMIISAVPWGFIADTIGRRPVLISGGWLDGFFVLCASLSQNTAQLMAFKFF 127
            |...||||..:.|.||:..|...|.:||.:||:.||.....::..|...:|..|.....:..:..
  Rat   143 SSSKKGMLGLIVYLGMMAGAFILGGLADKLGRKKVLSMSLAINASFASLSSFVQGYGAFLFCRLI 207

  Fly   128 DGLIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLP-VPILFTV-SSMK 190
            .|:.|.|...:|.:|.:||..::.|...:.::|:....|.:....:::.::| ....|:: ::..
  Rat   208 SGIGIGGSLPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGIYASAMAWSIIPHYGWGFSMGTNYH 272

  Fly   191 FRTWQVFLAVSSAPSLLSGFLHIFLPESPKFLMSQGNYKKALDSLQRIYKLNKRKS---RESYPI 252
            |.:|:||:.|.:.|:.:|.....|:||||:||:..|.:.:|...|::::..|.|..   .:.:.:
  Rat   273 FHSWRVFVIVCALPATVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTV 337

  Fly   253 KHLTDPTPDRSDDL----DGTGRPSTLQERFSRAQSKFIDGFKQL--KPMF--SSPYLAISLQVY 309
            .|:  .||.:.|:.    ..||      ..:.|...:|:..|||:  ..::  ..||...:|.:.
  Rat   338 SHI--KTPKQMDEFIEIQSSTG------TWYQRWLVRFMTIFKQVWDNALYCVMGPYRMNTLILA 394

  Fly   310 CLHFCQIMCVNSVRLWLPQIF---------ATMNAMDTLGANDTSMCAVLEHNANAKSMDEEEKR 365
            .:.|...:....:.:|.|.:.         :.|........:..::...:|:..:.......:|.
  Rat   395 VVWFTMALSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVHGATINFTMENQIHQHGKLVNDKF 459

  Fly   366 VECALHH-----------------DPDSYLNNITVAGIGLVGF-LIIFPLMRFQVVSNHILKV-- 410
            ::....|                 ..|:|..|.|:........ |.....:..:.:::..|:.
  Rat   460 IKMYFKHVLFEDTFFDKCYFEDVTSTDTYFKNCTIESTTFYNTDLYKHKFIDCRFINSTFLEQKE 524

  Fly   411 -----------FLFICIFLVGSLYFVKTSLV----------------TMMVSAV---YL------ 439
                       ||...:..:|||..:..:::                :|::|||   :|
  Rat   525 GCHMDFEEDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSE 589

  Fly   440 -TMMG----ICATTIIG------MSVVIFPTLMRTMVLLLIMTFGRLGSVSGNMLLPVFMQLSCL 493
             .|:|    .|.|:|..      ::|.::||..|.....::....:||::.||.:...|:.::.:
  Rat   590 SAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKLGAILGNTIFASFVGITKV 654

  Fly   494 APFLWLCSLMSIAFLFSLFLKVDDEQSL 521
            .|.|...:.:....|.:|.|....||.|
  Rat   655 VPILLAAASLVGGGLVALRLPETREQVL 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	MFS	30..>216	CDD:119392	51/187 (27%)
Sv2b	NP_476555.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..72
		synapt_SV2	8..683	CDD:130366	133/613 (22%)
		MFS	112..>305	CDD:119392	56/195 (29%)
		MFS	534..>675	CDD:119392	28/140 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920