Protein Alignment CG14691 and SLC22A12

DIOPT Version :10

• Sequence 1: NP_650012.2
• Gene: CG14691 / 41287
• FlyBaseID: FBgn0037829
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: XP_006718493.1
• Gene: SLC22A12 / 116085
• HGNCID: 17989
• Length: 578
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 106/543 - (19%)
• Similarity: 175/543 - (32%)
• Gaps: 169/543 - (31%)

  Fly    37 PCLTAMVFSASALSYVMP---SAECDLDLSIVDKGMLHAVTYAGMIISAVPWGFIADTIGRRPVL 98
            ||:...|:..|..:..:.   :..||   |...|.|..::..||:::.|...|..:|..|||.||
Human   115 PCVDGWVYDRSIFTSTIVAKWNLVCD---SHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVL 176

  Fly    99 -----------ISGGWLDGFFVLC----------ASLSQNTAQL---MAFKFFDGLIICGPFAVV 139
                       .:..:...|.|.|          |.:..||..|   :.::...|| ..|..|..
Human   177 TWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGL-HAGSRAEP 240

  Fly   140 VSYLA--EFHGKKHRPYIMLFVGLCVSIGSMILPLLSYLLLPVPILFTVSSMKFRTWQVFLAVSS 202
            :..||  |:...:.||.:|....|..|.|..:...::|              ..|.|.:...|.|
Human   241 LGLLAVMEWTAARARPLVMTLNSLGFSFGHGLTAAVAY--------------GVRDWTLLQLVVS 291

  Fly   203 APSLLSGFLHIFLPESPKFLMSQGNYKKALDSLQRIYKLNKRKSRESYPIKHLTDPTPDRSDDLD 267
            .|..|......:|.||.::|::.|.....|..|.|:..:|.:.:.:               |.|.
Human   292 VPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQ---------------DTLT 341

  Fly   268 GTGRPSTLQERFSRAQSKFIDGFKQLKP--------------MFSSPYLAISLQVYCLHFCQIMC 318
            .....|.::|..|..|.....|.....|              .|...:..::|.:..|
Human   342 PEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQAL------- 399

  Fly   319 VNSVRLWLPQIF-------ATMNA---MDTLGANDTSMCAVLEHN----ANAKSMDEEEKRVECA 369
              ...::|.|:|       |.|.|   :..||...|...::|...    ||.            .
Human   400 --GSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANT------------L 450

  Fly   370 LHHDPDSYLNNITVAGIGLVGFLIIFPLMRFQVVSNHILKVFLFICIFLVGSLYFVKTSLVTMMV 434
            :.|:..:..:.:.|.|:|.||                    ..|.||.:..|
Human   451 VPHEMGALRSALAVLGLGGVG--------------------AAFTCITIYSS------------- 482

  Fly   435 SAVYLTMMGICATTIIGMSVVIFPTLMRTMVLLLIMTFGRLGSVSGNMLLPVFMQLSCLAPFLWL 499
                                .:|||::|    :..:..|::.:..|.:|.|:...|....|:|.|
Human   483 --------------------ELFPTVLR----MTAVGLGQMAARGGAILGPLVRLLGVHGPWLPL 523

  Fly   500 CSLMSIAFLFSL-FLKVDDEQSL 521
            ....::..|..| .|.:.:.|||
Human   524 LVYGTVPVLSGLAALLLPETQSL 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	synapt_SV2	2..>337	CDD:130366	72/352 (20%)
		MFS	<375..513	CDD:475125	23/138 (17%)
SLC22A12	XP_006718493.1	MFS_OAT	109..541	CDD:340932	103/536 (19%)