Protein Alignment CG14691 and SLC22A7

DIOPT Version :10

• Sequence 1: NP_650012.2
• Gene: CG14691 / 41287
• FlyBaseID: FBgn0037829
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: XP_011512558.1
• Gene: SLC22A7 / 10864
• HGNCID: 10971
• Length: 610
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 125/590 - (21%)
• Similarity: 207/590 - (35%)
• Gaps: 227/590 - (38%)

  Fly    10 DEPA-------------DFETAIA-ECGFGLFNVFILCSAVPC------------------LTAM 42
            ||||             :|.:.|| |...|   ::|:...|.|                  ..|.
Human   106 DEPATVPCSQGWEYDHSEFSSTIATESQVG---IYIIHLEVECRWRQSPWEAAGRGLPWEEAEAA 167

  Fly    43 VFSASALSYVMPS---------AECDLDLSIVDKGMLHAVT---YAGMIISAVPWGFIADTIGRR 95
            ......:|| .||         :..:.||....||:..|.:   :||:::.||.:|:::|..|||
Human   168 GLGRDKVSY-SPSWRESLGGLLSGMEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRR 231

  Fly    96 PVLISGGWLDGFFVLCASLSQNTAQLMAFKFF------DGLIICGPFAVVVSYLA----EFHGKK 150
            .:|:..      :|....|...:|..:::..|      .|..:.| |.::|..|.    |:...:
Human   232 RLLLVA------YVSTLVLGLASAASVSYVMFAITRTLTGSALAG-FTIIVMPLGEAELEWLDVE 289

  Fly   151 HRPYIMLFVGLCVSIGSMILPLLSYLLLPVPILFTVSSMKFRTWQ-VFLAVS--SAPSLLSGFLH 212
            ||....:......:.|.|:|.|:.||:              |.|: :.|||:  .||.:||.:
Human   290 HRTVAGVLSSTFWTGGVMLLALVGYLI--------------RDWRWLLLAVTLPCAPGILSLW-- 338

  Fly   213 IFLPESPKFLMSQGNYKKALDSLQRIYKLNKRKSRESYPIKHLTDPTPDRSDDLDGTGRPSTLQE 277
             ::|||.::|::||:.|:|...|....:||                           ||| ..::
Human   339 -WVPESARWLLTQGHVKEAHRYLLHCARLN---------------------------GRP-VCED 374

  Fly   278 RFSR-AQSKFIDGFKQLK-----PMFSSPYLA-ISLQVYCLHFCQIMCVNSVRLWLPQIFATMNA 335
            .||: |.||...|.:.::     .:|.:|.|. |||           |
Human   375 SFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISL-----------C----------------- 411

  Fly   336 MDTLGANDTSMCAVLEHNANAKSMDEEEKRVECALHHDPDSYLN-NITVAGIGLVGFLIIFPLMR 399
                       |.|:....|.                   ||.. ::.|:|:||
Human   412 -----------CVVVWFGVNF-------------------SYYGLSLDVSGLGL----------- 435

  Fly   400 FQVVSNHIL--------KVFLFICIFLVG------------SLYFVKTSLVT--MMVSAVYLTMM 442
             .|....:|        |:.:::.:...|            :|.|....||:  |...:..|.:|
Human   436 -NVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVM 499

  Fly   443 G-----ICATTIIGMSVVIFPTLMRTMVLLLIMTFGRLGSVSGNMLLPVFMQLSCLAPFLWLCSL 502
            |     ...||....:..::||::|...:.|....|||    |..|.|    |:.|...:|| ||
Human   500 GKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRL----GGSLAP----LAALLDGVWL-SL 555

  Fly   503 MSIAF 507
            ..:.:
Human   556 PKLTY 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14691	NP_650012.2	synapt_SV2	2..>337	CDD:130366	86/390 (22%)
		MFS	<375..513	CDD:475125	36/161 (22%)
SLC22A7	XP_011512558.1	MFS	106..563	CDD:475125	125/590 (21%)